110963-25-2Relevant academic research and scientific papers
One-step ring-closure procedure for 4,5-dihydro-1,3-thiazino[5,4-b]indole derivatives with Lawesson's reagent. the fifth dihydro-1,3-thiazino[b]indole isomer
Csomos, Peter,Fodor, Lajos,Bernath, Gabor,Csampai, Antal,Sohar, Pal
experimental part, p. 1079 - 1084 (2011/11/06)
We report a convenient approach for the synthesis of a new ring system: 4,5-dihydro-1,3-thiazino[5,4-b]indoles. The procedure involves the use of Lawesson's reagent in the presence of silica to achieve the one-step ring-closure reactions of 2-benzoylamino-3-hydroxymethylindole intermediates to furnish 4,5-dihydro-2-aryl-1,3-thiazino[5,4-b]indoles. 2-Phenylimino-1,3- thiazino[5,4-b]indoles were obtained via the corresponding 3-phenylthiourea-2- carboxylic acid ester derivatives by chemoselective reduction of the ester group, followed by ring closure under acidic conditions. The structures of the novel products were elucidated by IR, 1H-NMR, and 13C-NMR spectroscopy, including 2D-HMQC, 2D-HMBC, and DEPT measurements.
Synthesis and transformations of ethyl 3-(benzoylamino)-1H-indole-2- carboxylates
Cucek, Karmen,Vercek, Bojan
, p. 1741 - 1746 (2008/12/22)
A number of ethyl 3-(benzoylamino)-lH-indole-2-car-boxylates were prepared by heating ethyl 2-(benzoylamino)-3-(phenylhydrazono)propanoates with polyphosphoric acid. The reaction of ethyl 3-(benzoylamino)-5-chloro-lH-indole- 2-carboxylate with hydrazine hydrate resulted in the formation of the debenzoylated hydrazide. Hydrolysis of the same ester with aqueous sodium hydroxide afforded 3-(benzoylamino)-5-chloro-lH-indole-2-carbox-ylic acid, which on heating underwent a decarboxylation reaction to givei N-(5-chloro-lH-indol- 3-yl)benzamide.
CERTAIN ARYL FUSED PYRROLOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS
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, (2008/06/13)
The present invention encompasses structures of the formula: STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein: STR2 and X represents hydrogen, halogen, or hydroxy; W represents an aryl group unsubstituted or substituted with
