7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,6-dihydro-3-methyl- (7CI,9CI)

Base Information

• Chemical Name: 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,6-dihydro-3-methyl- (7CI,9CI)
• CAS No.: 5399-94-0
• Molecular Formula: C₆H₆N₄O
• Molecular Weight: 150.14
• Hs Code.: 2933990090
• Mol file: 5399-94-0.mol

Synonyms:1H-Pyrazolo[4,3-d]pyrimidin-7-ol,3-methyl- (6CI,8CI); 7-Hydroxy-3-methylpyrazolo[4,3-d]pyrimidine; NSC 4941

Chemical Property of 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,6-dihydro-3-methyl- (7CI,9CI)

Chemical Property:

• Vapor Pressure: 2.25E-07mmHg at 25°C
• Melting Point: >300 °C
• Boiling Point: 423.4ºC at 760 mmHg
• PKA: 10.92±0.20(Predicted)
• Flash Point: 209.8ºC
• PSA: 74.43000
• Density: 1.72g/cm3
• LogP: -0.04540

Purity/Quality:

97% ^*data from raw suppliers

1,6-DIHYDRO-3-METHYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,6-dihydro-3-methyl- (7CI,9CI)

There total 7 articles about 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,6-dihydro-3-methyl- (7CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-formylamino-3-methylpyrazole-5-carboxamide → 7-hydroxy-3-methylpyrazolo[4,3-d]pyrimidine (5399-94-0)

Guidance literature:

With sodium methylate; In N-methyl-acetamide;

Reference yield:

3-methyl-4-nitropyrazole-5-carboxylic acid (5334-38-3) → 3-methyl-7-oxo-6,7-dihydro-1H-pyrazolo<4,3-d>pyrimidine (5399-94-0)

Guidance literature:

Multi-step reaction with 4 steps

2: water; NH₃

3: ethanol; palladium/charcoal / Hydrogenation

With palladium on activated charcoal; ethanol; ammonia; water;

DOI:10.1021/jo01114a001

Reference yield:

5-methyl-4-nitro-1(2)H-pyrazole-3-carboxylic acid amide (5334-36-1) → 3-methyl-7-oxo-6,7-dihydro-1H-pyrazolo<4,3-d>pyrimidine (5399-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; palladium/charcoal / Hydrogenation

With palladium on activated charcoal; ethanol;

DOI:10.1021/jo01114a001

upstream raw materials:

4-amino-5-methyl-1H-pyrazole-3-carboxamide

formamide

4-amino-5-methyl-1⁽²⁾H-pyrazole-3-carboxylic acid

5-methyl-4-nitro-1⁽²⁾H-pyrazole-3-carboxylic acid amide

Downstream raw materials:

dimethyl-(3-methyl-1(2)H-pyrazolo[4,3-d]pyrimidin-7-yl)-amine

3-methyl-1(2)H-pyrazolo[4,3-d]pyrimidine

7-Amino-3-methylpyrazolo<4,3-d>pyrimidin

7-chloro-3-methylpyrazolo[4,3-d]pyrimidine

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