Cyclohexaneacetic acid, 1-(3-hydroxy-1-propenyl)-, phenylmethyl ester, (E)-

Base Information

Chemical Name:Cyclohexaneacetic acid, 1-(3-hydroxy-1-propenyl)-, phenylmethyl ester, (E)-
CAS No.:138971-80-9
Molecular Formula:C₁₈H₂₄O₃
Molecular Weight:288.387
Hs Code.:

Synonyms:

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Chemical Property of Cyclohexaneacetic acid, 1-(3-hydroxy-1-propenyl)-, phenylmethyl ester, (E)-

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Technology Process of Cyclohexaneacetic acid, 1-(3-hydroxy-1-propenyl)-, phenylmethyl ester, (E)-

There total 11 articles about Cyclohexaneacetic acid, 1-(3-hydroxy-1-propenyl)-, phenylmethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [1-((E)-2-Chlorocarbonyl-vinyl)-cyclohexyl]-acetic acid benzyl ester

: 138971-80-9
[1-((E)-3-Hydroxy-propenyl)-cyclohexyl]-acetic acid benzyl ester

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; Yield given;
DOI:10.1016/0040-4039(91)80476-M

Reference yield:

: (1-Chlorocarbonylmethyl-cyclohexyl)-acetic acid benzyl ester

: 138971-80-9
[1-((E)-3-Hydroxy-propenyl)-cyclohexyl]-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: diethyl ether / 0 °C

2: AgOCOPh, Et₃N / Ambient temperature

3: H₂ / Pd/C / methanol

4: 1.) LDA / 1.) THF, -78 deg C to -20 deg C, 2.) -78 deg C

5: NaIO₄ / methanol / 0 °C

6: CaCO₃ / toluene / Heating

7: 1.) 1 N aq. NaOH, 2.) 1 N aq. HCl / 1.) MeOH, room temperature, 2.) room temperature

8: DCC, DMAP / CH₂Cl₂

9: 99 percent / TFA / CH₂Cl₂ / Ambient temperature

10: (COCl)2 / toluene / Ambient temperature

11: NaBH₄ / tetrahydrofuran / 0 °C

With hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; oxalyl dichloride; hydrogen; silver benzoate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; calcium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1016/0040-4039(91)80476-M

Reference yield:

: 113009-25-9
1,1,-Cyclohexanediacetic acid monobenzyl ester

: 138971-80-9
[1-((E)-3-Hydroxy-propenyl)-cyclohexyl]-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: (COCl)2 / toluene / Ambient temperature

2: diethyl ether / 0 °C

3: AgOCOPh, Et₃N / Ambient temperature

4: H₂ / Pd/C / methanol

5: 1.) LDA / 1.) THF, -78 deg C to -20 deg C, 2.) -78 deg C

6: NaIO₄ / methanol / 0 °C

7: CaCO₃ / toluene / Heating

8: 1.) 1 N aq. NaOH, 2.) 1 N aq. HCl / 1.) MeOH, room temperature, 2.) room temperature

9: DCC, DMAP / CH₂Cl₂

10: 99 percent / TFA / CH₂Cl₂ / Ambient temperature

11: (COCl)2 / toluene / Ambient temperature

12: NaBH₄ / tetrahydrofuran / 0 °C

With hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; oxalyl dichloride; hydrogen; silver benzoate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; calcium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1016/0040-4039(91)80476-M