Technology Process of Cyclohexaneacetic acid, 1-(2-carboxyethenyl)-, a-(phenylmethyl) ester,
(E)-
There total 9 articles about Cyclohexaneacetic acid, 1-(2-carboxyethenyl)-, a-(phenylmethyl) ester,
(E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: (COCl)2 / toluene / Ambient temperature
2: diethyl ether / 0 °C
3: AgOCOPh, Et3N / Ambient temperature
4: H2 / Pd/C / methanol
5: 1.) LDA / 1.) THF, -78 deg C to -20 deg C, 2.) -78 deg C
6: NaIO4 / methanol / 0 °C
7: CaCO3 / toluene / Heating
8: 1.) 1 N aq. NaOH, 2.) 1 N aq. HCl / 1.) MeOH, room temperature, 2.) room temperature
9: DCC, DMAP / CH2Cl2
10: 99 percent / TFA / CH2Cl2 / Ambient temperature
With
hydrogenchloride; dmap; sodium hydroxide; sodium periodate; oxalyl dichloride; hydrogen; silver benzoate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; calcium carbonate; lithium diisopropyl amide;
palladium on activated charcoal;
In
methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1016/0040-4039(91)80476-M
- Guidance literature:
-
Multi-step reaction with 9 steps
1: diethyl ether / 0 °C
2: AgOCOPh, Et3N / Ambient temperature
3: H2 / Pd/C / methanol
4: 1.) LDA / 1.) THF, -78 deg C to -20 deg C, 2.) -78 deg C
5: NaIO4 / methanol / 0 °C
6: CaCO3 / toluene / Heating
7: 1.) 1 N aq. NaOH, 2.) 1 N aq. HCl / 1.) MeOH, room temperature, 2.) room temperature
8: DCC, DMAP / CH2Cl2
9: 99 percent / TFA / CH2Cl2 / Ambient temperature
With
hydrogenchloride; dmap; sodium hydroxide; sodium periodate; hydrogen; silver benzoate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; calcium carbonate; lithium diisopropyl amide;
palladium on activated charcoal;
In
methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1016/0040-4039(91)80476-M
