Chemical Property of 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde
Chemical Property:
- Melting Point:189-190℃ (ethanol )
- Refractive Index:1.641
- Boiling Point:398.3±42.0 °C(Predicted)
- PKA:6.22±0.20(Predicted)
- PSA：67.51000
- Density:1.541
- LogP:1.61950
- Storage Temp.:?20°C
- Solubility.:DMSO: soluble5mg/mL, clear (warmed)
- XLogP3:1.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:1
- Exact Mass:204.04225873
- Heavy Atom Count:15
- Complexity:321
- Purity/Quality:
-
99%, *data from raw suppliers
4u8C *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=O)OC2=C1C=CC(=C2C=O)O
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Description
4μ8C (14003-96-4) is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50?= 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity.1?Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells.2?Blocks production of IL-4, IL-5 and IL-13 production in T cells.3?4μ8C prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells.4
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Uses
8-Formyl-4-methylumbelliferone is an inhibitor that blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation.
