N-(2-(Dimethylamino)ethyl)benzamide

Base Information

• Chemical Name: N-(2-(Dimethylamino)ethyl)benzamide
• CAS No.: 63224-18-0
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.261
• UNII: 27ABH63ALF
• DSSTox Substance ID: DTXSID30212593
• Nikkaji Number: J1.165.319G
• Wikidata: Q27254191
• ChEMBL ID: CHEMBL1478422
• Mol file: 63224-18-0.mol

Synonyms:N-(2-(Dimethylamino)ethyl)benzamide;63224-18-0;n-[2-(dimethylamino)ethyl]benzamide;Benzamide, N-(2-(dimethylamino)ethyl)-;27ABH63ALF;Benzamide, N-[2-(dimethylamino)ethyl]-;GC 25;UNII-27ABH63ALF;BRN 1951676;N-(2-dimethylaminoethyl)benzamide;Oprea1_247320;4-09-00-00860 (Beilstein Handbook Reference);MLS000564209;SCHEMBL2087431;CHEMBL1478422;DTXSID30212593;LBZUJSQLLVDWDQ-UHFFFAOYSA-N;HMS1762E11;HMS2402P10;AKOS001051312;NCGC00246052-01;SMR000151696;CS-0295457;Q27254191;Z32020426

Chemical Property of N-(2-(Dimethylamino)ethyl)benzamide

Chemical Property:

• Vapor Pressure: 3.21E-05mmHg at 25°C
• Boiling Point: 355°Cat760mmHg
• Flash Point: 168.5°C
• Density: 1.03g/cm³
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 192.126263138
• Heavy Atom Count: 14
• Complexity: 174

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCNC(=O)C1=CC=CC=C1

Technology Process of N-(2-(Dimethylamino)ethyl)benzamide

There total 7 articles about N-(2-(Dimethylamino)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

benzoyl chloride (98-88-4) + N,N-dimethylethylenediamine (108-00-9) → N-(2-(dimethylamino)ethyl)benzamide (63224-18-0)

Guidance literature:

In diethyl ether; dichloromethane; for 0.5h;

DOI:10.1002/hlca.19830660215

Reference yield: 59.0%

N-(2-dimethylamino-ethyl)-2-fluoro-benzamide → N-(2-(dimethylamino)ethyl)benzamide (63224-18-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; for 0.5h;

DOI:10.1016/S0040-4039(99)01397-0

Reference yield: 48.0%

N-(N',N'-dimethylaminoethyl)-2-iodobenzamide (77617-04-0) → N-(2-(dimethylamino)ethyl)benzamide (63224-18-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; for 0.5h;

DOI:10.1016/S0040-4039(99)01397-0

upstream raw materials:

benzoic acid ethyl ester

N,N-dimethylethylenediamine

benzoyl chloride

N-(N',N'-dimethylaminoethyl)-2-iodobenzamide

Downstream raw materials:

N-(2-Dimethylamino-ethyl)-2-methoxy-benzamide

N-(2-Dimethylamino-ethyl)-thiobenzamide