1-METHYLADENINE

Base Information

• Chemical Name: 1-METHYLADENINE
• CAS No.: 5142-22-3
• Molecular Formula: C6H7N5
• Molecular Weight: 149.155
• Hs Code.: 29335995
• Mol file: 5142-22-3.mol

Synonyms:Adenine,1-methyl- (6CI,7CI,8CI);1-Methyl-6-aminopurine;1-Methyladenine;6-Amino-1-methylpurine;N1-Methyladenine;NSC 70896;

Chemical Property of 1-METHYLADENINE

Chemical Property:

• Appearance/Colour: Pale yellow or beige crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 300 °C
• Refractive Index: 1.807
• Boiling Point: 240.1 °C at 760 mmHg
• PKA: 9.18±0.20(Predicted)
• Flash Point: 99 °C
• PSA: 69.62000
• Density: 1.6 g/cm³
• LogP: 0.52670
• Storage Temp.: ?20°C

Purity/Quality:

99% ^*data from raw suppliers

1-Methyladenine 98.49% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYLADENINE

There total 4 articles about 1-METHYLADENINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

7-(3-Methoxy-benzyl)-1-methyl-1,7-dihydro-purin-6-ylideneamine (132213-04-8) → 1-methyladenine (5142-22-3)

Guidance literature:

In methanol; water; Irradiation;

DOI:10.1016/S0040-4039(00)97950-4

Reference yield:

dimethyl sulfate (77-78-1) + adenosine (58-61-7) → 1-methyladenine (5142-22-3) + 3-methyladenine (5142-23-4)

Guidance literature:

With potassium carbonate; N,N-dimethyl-formamide; anschliessendes Erwaermen mit wss.HCl;

DOI:10.1039/jr9600000539

Reference yield:

(2R,3S,5R)-2-Hydroxymethyl-5-(6-imino-1-methyl-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-ol; compound with toluene-4-sulfonic acid (100624-73-5) → 1-methyladenine (5142-22-3)

Guidance literature:

With hydrogenchloride; at 25 ℃; Kinetics; var. temperatures;

DOI:10.1248/cpb.42.495

upstream raw materials:

dimethyl sulfate

adenosine

7-(3-Methoxy-benzyl)-1-methyl-1,7-dihydro-purin-6-ylideneamine

(2R,3S,5R)-2-Hydroxymethyl-5-(6-imino-1-methyl-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-ol; compound with toluene-4-sulfonic acid

Downstream raw materials:

N-methyladenine

Refernces

• 1、 Er-Rhaimini, A.,Mohsinaly, N.,Mornet, R.. "The photosolvolysis of N-arylmethyladenines. Photoremovable N-arylmethyl protective groups for N-containing compounds". . p. 5757 - 5760. Retrieved 2007/10/02.