2H-Isoindole-2-propanoic acid, 1,3-dihydro-1,3-dioxo-b-pentyl-, methyl ester

Base Information

• Chemical Name: 2H-Isoindole-2-propanoic acid, 1,3-dihydro-1,3-dioxo-b-pentyl-, methyl ester
• CAS No.: 141627-79-4
• Molecular Formula: C17H21NO4
• Mol file: 141627-79-4.mol

Synonyms:

Chemical Property of 2H-Isoindole-2-propanoic acid, 1,3-dihydro-1,3-dioxo-b-pentyl-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Isoindole-2-propanoic acid, 1,3-dihydro-1,3-dioxo-b-pentyl-, methyl ester

There total 9 articles about 2H-Isoindole-2-propanoic acid, 1,3-dihydro-1,3-dioxo-b-pentyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methanol (67-56-1) + Se-phenyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octaneselenoate (777949-86-7) → Methyl 3-phthalimidooctanoate (141627-79-4)

Guidance literature:

With copper dichloride; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200400177

Reference yield:

(E)-oct-2-enoic acid (1871-67-6) → Methyl 3-phthalimidooctanoate (141627-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Amberlite IR-120 (H⁺) resin / 12 h

2: 163 mg / pyridine; EtONa / 24 h / Heating

With pyridine; Amberlite IR-120 (H⁺) resin; sodium ethanolate;

DOI:10.1021/jm061307x

Reference yield:

hexanal (66-25-1) → Methyl 3-phthalimidooctanoate (141627-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 12.9 g / pyridine, pyrrolidine / 0.5 h / Heating

2: diethyl ether

3: pyridine / EtONa / 24 h / Heating

With pyrrolidine; pyridine; sodium ethanolate; In diethyl ether;

DOI:10.1016/S0040-4020(01)88753-6

upstream raw materials:

phthalimide

methyl (E)-oct-2-enoate

methanol

Se-phenyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octaneselenoate

Downstream raw materials:

3-Amino octanoic acid

Refernces

• 1、 Tiecco, Marcello,Testaferri, Lorenzo,Temperini, Andrea,Bagnoli, Luana,Marini, Francesca,Santi, Claudio,Terlizzi, Raffaella. "Synthesis of substituted Se-phenyl selenocarboxylates from terminal alkynes". . p. 3447 - 3458. Retrieved 2007/10/03.