3-Isothiazolamine, N,N-diethyl-4-(4-methoxyphenyl)-, 1,1-dioxide

Base Information

Chemical Name:3-Isothiazolamine, N,N-diethyl-4-(4-methoxyphenyl)-, 1,1-dioxide
CAS No.:141855-74-5
Molecular Formula:C14H18N2O3S
Molecular Weight:294.375
Hs Code.:
DSSTox Substance ID:DTXSID60446980
Nikkaji Number:J604.340B
ChEMBL ID:CHEMBL305232
Mol file:141855-74-5.mol

Synonyms:3-Isothiazolamine, N,N-diethyl-4-(4-methoxyphenyl)-, 1,1-dioxide;141855-74-5;CHEMBL305232;DTXSID60446980;3-(Diethylamino)-4-(4-methoxyphenyl)isothiazole 1,1-dioxide

Suppliers and Price of 3-Isothiazolamine, N,N-diethyl-4-(4-methoxyphenyl)-, 1,1-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3-Isothiazolamine, N,N-diethyl-4-(4-methoxyphenyl)-, 1,1-dioxide

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:294.10381361
Heavy Atom Count:20
Complexity:493

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)C1=NS(=O)(=O)C=C1C2=CC=C(C=C2)OC

Technology Process of 3-Isothiazolamine, N,N-diethyl-4-(4-methoxyphenyl)-, 1,1-dioxide

There total 13 articles about 3-Isothiazolamine, N,N-diethyl-4-(4-methoxyphenyl)-, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 141855-68-7
4-chloro-3-diethylamino-4-(4-methoxyphenyl)-4,5-dihydroisothiazole-1,1-dioxide

: 141855-74-5
4-chloro-3-diethylamino-4-(4-methoxyphenyl)-4,5H-isothiazolin-1,1-dioxide

Guidance literature:: With potassium carbonate; In acetone; for 120h; Inert atmosphere; Reflux;
DOI:10.1039/c5ob02586a

Reference yield: 70.0%

: 960-16-7
tributylphenylstannane

: 199383-67-0
5-bromo-3-diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide

: 141855-74-5
4-chloro-3-diethylamino-4-(4-methoxyphenyl)-4,5H-isothiazolin-1,1-dioxide

: 141855-24-5
Diethyl-[4-(4-methoxy-phenyl)-1,1-dioxo-5-phenyl-1H-1λ⁶-isothiazol-3-yl]-amine

Guidance literature:: benzoylchlorobis(triphenylphosphine)palladium(II); In toluene; at 110 ℃; for 1h;
DOI:10.1016/S0040-4020(97)10046-1

Reference yield: 35.0%

: 7486-35-3
tri-n-butyl(vinyl)tin

: 141855-74-5
4-chloro-3-diethylamino-4-(4-methoxyphenyl)-4,5H-isothiazolin-1,1-dioxide

: 2-[3-Diethylamino-4-(4-methoxy-phenyl)-1,1-dioxo-1H-1λ⁶-isothiazol-5-yl]-acrylic acid methyl ester

Guidance literature:: With methyl 2-(tributylstannanyl)-2-propenoate; benzoylchlorobis(triphenylphosphine)palladium(II); In toluene; at 110 ℃; for 4h; other reagents: tri(n-butyl)vinylstannane, tri(n-butyl)phenylstannane, tri(n-butyl)(2-pyridyl)stannane, 1-(ethoxycarbonyl)indolyl-3-tri(n-butyl)stannane, 1-ethoxyvinyltributylstannane, other catalyst: (PPh₃)2Cl₂Pd;
DOI:10.1016/S0040-4020(97)10046-1