3-diethylamino-4-(4-methoxyphenyl)-5-methylsulfanyl-isothiazole 1,1-dioxide

Base Information

Chemical Name:3-diethylamino-4-(4-methoxyphenyl)-5-methylsulfanyl-isothiazole 1,1-dioxide
CAS No.:222311-17-3
Molecular Formula:C₁₅H₂₀N₂O₃S₂
Molecular Weight:340.467
Hs Code.:

Synonyms:3-diethylamino-4-(4-methoxyphenyl)-5-methylsulfanyl-isothiazole 1,1-dioxide

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Chemical Property of 3-diethylamino-4-(4-methoxyphenyl)-5-methylsulfanyl-isothiazole 1,1-dioxide

Chemical Property:

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Technology Process of 3-diethylamino-4-(4-methoxyphenyl)-5-methylsulfanyl-isothiazole 1,1-dioxide

There total 6 articles about 3-diethylamino-4-(4-methoxyphenyl)-5-methylsulfanyl-isothiazole 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 199383-67-0
5-bromo-3-diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide

: 5188-07-8
sodium thiomethoxide

: 222311-17-3
3-diethylamino-4-(4-methoxyphenyl)-5-methylsulfanyl-isothiazole 1,1-dioxide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1039/c5ob02586a

Reference yield:

: 141855-27-8
2-diethylamino-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one

: 222311-17-3
3-diethylamino-4-(4-methoxyphenyl)-5-methylsulfanyl-isothiazole 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 22 h / Inert atmosphere; Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 2 h / Inert atmosphere

3.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

3.2: 192 h / Inert atmosphere; Reflux

4.1: bromine / dichloromethane; tetrachloromethane / 2 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With thionyl chloride; potassium tert-butylate; bromine; triethylamine; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane;
DOI:10.1039/c5ob02586a

Reference yield:

: 7145-87-1
2,3-dibromo-1-(4-methoxyphenyl)-3-phenylpropan-1-one

: 222311-17-3
3-diethylamino-4-(4-methoxyphenyl)-5-methylsulfanyl-isothiazole 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 26 h / 20 °C / Inert atmosphere

2.1: ethanol / 22 h / Inert atmosphere; Reflux

3.1: potassium tert-butylate / tetrahydrofuran / 2 h / Inert atmosphere

4.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

4.2: 192 h / Inert atmosphere; Reflux

5.1: bromine / dichloromethane; tetrachloromethane / 2 h / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With thionyl chloride; potassium tert-butylate; bromine; triethylamine; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane;
DOI:10.1039/c5ob02586a