Phosphoramidic acid, N,N-diethyl-, diethyl ester

Base Information

• Chemical Name: Phosphoramidic acid, N,N-diethyl-, diethyl ester
• CAS No.: 3167-69-9
• Molecular Formula: C8H20 N O3 P
• Molecular Weight: 209.225
• DSSTox Substance ID: DTXSID00185563
• Nikkaji Number: J2.135.163F
• Mol file: 3167-69-9.mol

Synonyms:Phosphoramidic acid, N,N-diethyl-, diethyl ester;diethyl diethylphosphoramidate;3167-69-9;SCHEMBL3289373;DTXSID00185563;STL563542;AKOS030516140;(Diethylamino)phosphonic acid diethyl ester

Chemical Property of Phosphoramidic acid, N,N-diethyl-, diethyl ester

Chemical Property:

• Vapor Pressure: 0.0523mmHg at 25°C
• Boiling Point: 234.6°Cat760mmHg
• Flash Point: 95.7°C
• Density: 1.022g/cm³
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 209.11808050
• Heavy Atom Count: 13
• Complexity: 161

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)P(=O)(OCC)OCC

Technology Process of Phosphoramidic acid, N,N-diethyl-, diethyl ester

There total 6 articles about Phosphoramidic acid, N,N-diethyl-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

diethyl chlorophosphate (814-49-3) + N,N-diethyl-3-phenyl-1,3,2-oxazaphospholidin-2-amine (31707-09-2) → diethyl-amidophosphoric acid diethyl ester (3167-69-9) + 2-chloro-3-phenyl-[1,3,2]oxazaphospholidine (31707-07-0)

Guidance literature:

at 100 ℃; for 1h;

DOI:10.1007/BF00954291

Reference yield: 80.0%

Diethyl phosphonate (762-04-9,123-22-8) + N,N-diethylbenzo[d]thiazole-2-sulfenamide (2720-65-2) → diethyl-amidophosphoric acid diethyl ester (3167-69-9) + 2-Mercaptobenzothiazole (149-30-4,118090-09-8)

Guidance literature:

DOI:10.1246/cl.1980.695

Reference yield: 73.0%

1,2-dibromo-1,1,2,2-tetrafluoroethane (124-73-2) + diethylamine (109-89-7) + phosphonic acid diethyl ester (762-04-9) → polytetrafluoroethylene (116-14-3,82785-14-6) + diethyl-amidophosphoric acid diethyl ester (3167-69-9)

Guidance literature:

at 0 - 20 ℃;

upstream raw materials:

diethyl ether

N-chlorodiethylamine

phosphonic acid diethyl ester

diethyl chlorophosphate

Refernces

• 1、 Albrecht, Steffen,Herrmann, Eckhard. "DIREKTSYNTHESE VON N,N-DIORGANYL-PHOSPHORSAEUREDIALKYLESTERAMIDEN AUS TRIALKYLPHOSPHITEN". . p. 189 - 192. Retrieved 2007/10/02.
• 2、 Torii, Sigeru,Sayo, Noboru,Tanaka, Hideo. "REACTION OF SULFENAMIDES WITH DI-ALKYL AND TRIALKYL PHOSPHITES. AN EFFICIENT SYNTHESIS OF PHOSPHORAMIDATES BY UNUSUAL SUBSTITUTION AT S-N BOND IN (2-BENZOTHIAZOLYL)SULFENAMIDES". . p. 695 - 698. Retrieved 2007/10/02.