N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

Base Information

Chemical Name:N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine
CAS No.:81256-88-4
Molecular Formula:C44H49N5O7Si
Molecular Weight:787.988
Hs Code.:
Mol file:81256-88-4.mol

Synonyms:5'-DMT-3'-TBDMS-Bz-rA;N6-BENZOYL-3'-O-TERT-BUTYLDIMETHYLSILYL-5'-O-DMT-ADENOSINE;

Suppliers and Price of N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5'-DMT-3'-TBDMS-Bz-rA 95+%
10g
$ 1872.00

Crysdot
5'-DMT-3'-TBDMS-Bz-rA 95+%
25g
$ 3743.00

Crysdot
5'-DMT-3'-TBDMS-Bz-rA 95+%
1g
$ 396.00

Crysdot
5'-DMT-3'-TBDMS-Bz-rA 95+%
5g
$ 1169.00

Chemenu
N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 95%
5g
$ 1103.00

Chemenu
N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 95%
1g
$ 374.00

Biosynth Carbosynth
N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine
500 mg
$ 260.00

Biosynth Carbosynth
N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine
250 mg
$ 170.00

Biosynth Carbosynth
N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine
50 mg
$ 50.00

Biosynth Carbosynth
N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine
100 mg
$ 86.00

Total 15 raw suppliers

Chemical Property of N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

Chemical Property:

PSA：139.08000
LogP:7.82620
Storage Temp.:2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

5'-DMT-3'-TBDMS-Bz-rA 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

There total 4 articles about N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 129666-75-7,81246-82-4
6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 81256-88-4
N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

: 129681-71-6,81265-93-2
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine

Guidance literature:: With pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 29.3%

: 129666-75-7,81246-82-4
6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine

: 18162-48-6
tert-butyldimethylsilyl chloride

: C₅₀H₆₃N₅O₇Si₂

: 81256-88-4
N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

: 129681-71-6,81265-93-2
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine

Guidance literature:: With pyridine; 1H-imidazole; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 4546-55-8
N-benzoyladenosine

: 81256-88-4
N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; pyridine / 16 h / 0 - 20 °C

2: silver nitrate; pyridine / tetrahydrofuran / 16 h / 20 °C

With pyridine; dmap; silver nitrate; In tetrahydrofuran;