Benzenepropanoic acid, b-hydroxy-4-methyl-b-(trifluoromethyl)-, methyl ester, (S)-

Base Information

• Chemical Name: Benzenepropanoic acid, b-hydroxy-4-methyl-b-(trifluoromethyl)-, methyl ester, (S)-
• CAS No.: 142134-02-9
• Molecular Formula: C12H13F3O3
• Molecular Weight: 262.229
• Mol file: 142134-02-9.mol

Synonyms:

Chemical Property of Benzenepropanoic acid, b-hydroxy-4-methyl-b-(trifluoromethyl)-, methyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanoic acid, b-hydroxy-4-methyl-b-(trifluoromethyl)-, methyl ester, (S)-

There total 3 articles about Benzenepropanoic acid, b-hydroxy-4-methyl-b-(trifluoromethyl)-, methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + (2R,6S)-2-(tert-Butyl)-6-(4-methylen-cyclohexa-2,5-dienyl)-6-trifluormethyl-1,3-dioxan-4-on (156593-93-0) → (S)-4,4,4-Trifluor-3-hydroxy-3-(4-methylphenyl)buttersaeure-methylester (142134-02-9)

Guidance literature:

With hydrogenchloride;

Reference yield: 64.0%

methanol (67-56-1) + C17H14F4O2S → (S)-4,4,4-Trifluor-3-hydroxy-3-(4-methylphenyl)buttersaeure-methylester (142134-02-9)

Guidance literature:

methanol; With magnesium; at 0 ℃; for 0.166667h; Sealed tube;

C₁₇H₁₄F₄O₂S; at 20 ℃; for 2h; Sealed tube;

DOI:10.1021/acs.orglett.9b01469

Reference yield:

2,2,2-trifluoro-1-(p-tolyl)ethanone (394-59-2) → (S)-4,4,4-Trifluor-3-hydroxy-3-(4-methylphenyl)buttersaeure-methylester (142134-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: C₂₈H₂₆F₆N₄S / tetrahydrofuran; tert-butyl methyl ether / 96 h / -20 °C / Sealed tube; Inert atmosphere

2.1: magnesium / 0.17 h / 0 °C / Sealed tube

2.2: 2 h / 20 °C / Sealed tube

With C₂₈H₂₆F₆N₄S; magnesium; In tetrahydrofuran; tert-butyl methyl ether; 1.1: |Aldol Addition;

DOI:10.1021/acs.orglett.9b01469

upstream raw materials:

methanol

(2R,6S)-2-(tert-Butyl)-6-(4-methylen-cyclohexa-2,5-dienyl)-6-trifluormethyl-1,3-dioxan-4-on

2,2,2-trifluoro-1-(p-tolyl)ethanone