3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl 3-(2-methoxyethyl) ester

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl 3-(2-methoxyethyl) ester
CAS No.:142161-45-3
Molecular Formula:C32H31ClN4O5
Molecular Weight:587.075
Hs Code.:

3,5-Pyridinedicarboxylic acid,
4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5-
c]pyridin-1-yl)phenyl]-, 5-ethyl 3-(2-methoxyethyl) ester

Synonyms:

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Chemical Property of 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl 3-(2-methoxyethyl) ester

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Technology Process of 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl 3-(2-methoxyethyl) ester

There total 13 articles about 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl 3-(2-methoxyethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 142161-40-8,122957-04-4,122957-05-5
4-(2-chlorophenyl)-1,4-dihydro-3-(ethoxycarbonyl)-6-methyl-2-<4-(2-methylimidazo<4,5-c>pyrid-1-yl)phenyl>-pyridine-5-carboxylic acid

: 142161-45-3
4-(2-chlorophenyl)-1,4-dihydro-3-(ethoxycarbonyl)-5-<(2-methoxyethoxy)carbonyl>-6-methyl-2-<4-(2-methylimidazo-<4,5-c>pyrid-1-yl)phenyl>pyridine

Guidance literature:: With dmap; In hydrogenchloride; dichloromethane;

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 142161-45-3
4-(2-chlorophenyl)-1,4-dihydro-3-(ethoxycarbonyl)-5-<(2-methoxyethoxy)carbonyl>-6-methyl-2-<4-(2-methylimidazo-<4,5-c>pyrid-1-yl)phenyl>pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / ethanol / 18 h / 20 °C

2: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

3: 81 percent / acetic acid / 2 h / 90 °C

4: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

5: 44 percent / ethanol / 8 h / Heating

6: 96 percent / NaOH / dioxane; H₂O / 1 h / 20 °C

7: 1.) 2,4,6-triisopropylbenzenesulfonyl chloride, DMAP / 1.) CH₂Cl₂, 20 deg C, 3 h, 2.) CH₂Cl₂, 20 deg C, 20 h

With dmap; sodium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid;
DOI:10.1021/jm00095a005

Reference yield:

: 122957-33-9
4-[N-(4-cyanophenyl)amino]-3-nitropyridine

: 142161-45-3
4-(2-chlorophenyl)-1,4-dihydro-3-(ethoxycarbonyl)-5-<(2-methoxyethoxy)carbonyl>-6-methyl-2-<4-(2-methylimidazo-<4,5-c>pyrid-1-yl)phenyl>pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

2: 81 percent / acetic acid / 2 h / 90 °C

3: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

4: 44 percent / ethanol / 8 h / Heating

5: 96 percent / NaOH / dioxane; H₂O / 1 h / 20 °C

6: 1.) 2,4,6-triisopropylbenzenesulfonyl chloride, DMAP / 1.) CH₂Cl₂, 20 deg C, 3 h, 2.) CH₂Cl₂, 20 deg C, 20 h

With dmap; sodium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid;
DOI:10.1021/jm00095a005