1-Methyl-6-nitropyrido[2,3-d]pyrimidine-2,4-dione

Base Information

Chemical Name:1-Methyl-6-nitropyrido[2,3-d]pyrimidine-2,4-dione
CAS No.:142168-86-3
Molecular Formula:C8H6N4O4
Molecular Weight:0.00000
Hs Code.:
DSSTox Substance ID:DTXSID401198963
Mol file:142168-86-3.mol

Synonyms:1-methyl-6-nitropyrido[2,3-d]pyrimidine-2,4-dione;6-nitro-1-methylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione;Oprea1_335914;DTXSID401198963;142168-86-3;AB-323/13887166;1-Methyl-6-nitropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Suppliers and Price of 1-Methyl-6-nitropyrido[2,3-d]pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Methyl-6-nitropyrido[2,3-d]pyrimidine-2,4-dione

Chemical Property:

PSA：0.00000
LogP:0.00000
XLogP3:-0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:222.03890469
Heavy Atom Count:16
Complexity:352

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C2=C(C=C(C=N2)[N+](=O)[O-])C(=O)NC1=O

Technology Process of 1-Methyl-6-nitropyrido[2,3-d]pyrimidine-2,4-dione

There total 2 articles about 1-Methyl-6-nitropyrido[2,3-d]pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2434-53-9
6-amino-1-methyluracil

: 34461-00-2
nitromalondialdehyde sodium salt

: 142168-86-3
1-methyl-6-nitropyrido<2,3-d>pyrimidine-2,4-dione

Guidance literature:: With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.11.026

Reference yield: 61.0%

: 2434-53-9
6-amino-1-methyluracil

: 142168-86-3
1-methyl-6-nitropyrido<2,3-d>pyrimidine-2,4-dione

Guidance literature:: With sodium hydroxide; nitromalondialdehyde sodium salt; at 80 ℃; for 2h;
DOI:10.3987/COM-91-S100

Reference yield:

: 142168-86-3
1-methyl-6-nitropyrido<2,3-d>pyrimidine-2,4-dione

: 142168-92-1
6-benzylideneimino-1-methylpyrido<2,3-d>pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / 0.05 N aq. NaOH / methanol / 1 h / Ambient temperature

2: 84 percent / H₂, AcOH / 5percent Pd/C / ethanol; acetic acid

3: 77 percent / AcOH / 1 h / Ambient temperature

With sodium hydroxide; hydrogen; acetic acid; palladium on activated charcoal; In methanol; ethanol; acetic acid;
DOI:10.3987/COM-91-S100