6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9&

Base Information

• Chemical Name: 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9&
• CAS No.: 36684-65-8
• Molecular Formula: C12H12 Cl N
• Molecular Weight: 205.687
• Hs Code.: 2933990090
• Mol file: 36684-65-8.mol

Synonyms:Carbazole,6-chloro-1,2,3,4-tetrahydro- (6CI); 1,2,3,4-Tetrahydro-6-chlorocarbazole;6-Chloro-1,2,3,4-tetrahydrocarbazole; 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole;NSC 298291

Chemical Property of 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9&

Chemical Property:

• Vapor Pressure: 5.15E-05mmHg at 25°C
• Melting Point: 145-148 °C(lit.)
• Boiling Point: 358.8°Cat760mmHg
• PKA: 16.93±0.20(Predicted)
• Flash Point: 202.1°C
• PSA: 15.79000
• Density: 1.28g/cm³
• LogP: 3.70010
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: slightly sol. in Methanol

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9&

There total 26 articles about 6-CHLORO-1 2 3 4-TETRAHYDROCARBAZOLE 9& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5'-chloro-2'-nitro-2,3,4,5-tetrahydro-1,1'-biphenyl → 6-chloro-1,2,3,4-tetrahydrocarbazole (36684-65-8)

Guidance literature:

With hydrogenchloride; titanium(III) chloride; In water; acetonitrile; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/anie.201505713

Reference yield: 97.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + N-4-chlorophenylhydrazine (1073-69-4) → 6-chloro-1,2,3,4-tetrahydrocarbazole (36684-65-8)

Guidance literature:

With L-(+)-tartaric acid-urea melt; at 70 ℃; for 0.5h;

DOI:10.1021/ol302034r

Reference yield: 95.0%

4-chlorophenylhydrazine hydrochloride (1073-70-7) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 6-chloro-1,2,3,4-tetrahydrocarbazole (36684-65-8)

Guidance literature:

With 1,3-bis(3-sulfopropyl)-1H-imidazol-3-ium trifluoromethanesulfonate; In water; at 100 ℃; for 0.333333h; Microwave irradiation; Green chemistry;

DOI:10.1016/j.jfluchem.2012.09.010

upstream raw materials:

2-((4-chlorophenyl)amino)cyclohexan-1-one

4-chloro-aniline

cyclohexanone-2-ol

2-Chlorocyclohexanone

Downstream raw materials:

4a-benzyl-6-chloro-2,3,4,4a-tetrahydro-1H-carbazole

C₂₀H₁₈ClNO₂

(6-chloro-1,2,3,4-tetrahydro-9H-carbazol-9-yl) (phenyl) methanone

(4aS,9aS)-6-chloro-2,3,4,4a,9,9a-hexahydro-1H-carbazole