1-Methyl-2,3,6-triphenyl-4-piperidinamine hydrochloride

Base Information

• Chemical Name: 1-Methyl-2,3,6-triphenyl-4-piperidinamine hydrochloride
• CAS No.: 124069-21-2
• Molecular Formula: C24H26 N2
• Molecular Weight: 378.93758
• DSSTox Substance ID: DTXSID30924705
• Mol file: 124069-21-2.mol

Synonyms:1-Methyl-2,3,6-triphenyl-4-piperidinamine hydrochloride;124069-21-2;1-methyl-2,3,6-triphenylpiperidin-4-amine;4-Piperidinamine, 1-methyl-2,3,6-triphenyl-, hydrochloride;C24-H26-N2.Cl-H;DTXSID30924705;LS-113872

Chemical Property of 1-Methyl-2,3,6-triphenyl-4-piperidinamine hydrochloride

Chemical Property:

• Vapor Pressure: 5.36E-09mmHg at 25°C
• Boiling Point: 469.8°C at 760 mmHg
• Flash Point: 221.7°C
• PSA: 29.26000
• Density: 1.078g/cm³
• LogP: 6.35580
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 342.209598838
• Heavy Atom Count: 26
• Complexity: 418

Purity/Quality:

1-METHYL-2,3,6-TRIPHENYL-4-PIPERIDINAMINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(CC(C(C1C2=CC=CC=C2)C3=CC=CC=C3)N)C4=CC=CC=C4

Technology Process of 1-Methyl-2,3,6-triphenyl-4-piperidinamine hydrochloride

There total 4 articles about 1-Methyl-2,3,6-triphenyl-4-piperidinamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-methyl-2,3,6-triphenylpiperidin-4-one oxime (113849-85-7) → 1-Methyl-2,3,6-triphenyl-piperidin-4-ylamine (124069-21-2)

Guidance literature:

With sodium; In ethanol; for 3h; Heating;

DOI:10.1007/BF00758420

Reference yield:

1-methyl-2,3,6-triphenylpiperidin-4-one (71864-80-7) → 1-Methyl-2,3,6-triphenyl-piperidin-4-ylamine (124069-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / ethanol / 3 h / 85 °C

2: 68 percent / sodium / ethanol / 3 h / Heating

With hydroxylamine hydrochloride; sodium; In ethanol;

DOI:10.1007/BF00758420

Reference yield:

benzaldehyde (100-52-7) → 1-Methyl-2,3,6-triphenyl-piperidin-4-ylamine (124069-21-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 15 h / 20 °C

2: hydroxylamine hydrochloride / ethanol / 3 h / 85 °C

3: 68 percent / sodium / ethanol / 3 h / Heating

With hydroxylamine hydrochloride; sodium; In ethanol; acetic acid;

DOI:10.1007/BF00758420

upstream raw materials:

1-methyl-2,3,6-triphenylpiperidin-4-one oxime

1-methyl-2,3,6-triphenylpiperidin-4-one

benzaldehyde

1-phenyl-acetone

Downstream raw materials:

(1-Methyl-2,3,6-triphenyl-piperidin-4-yl)-[1-phenyl-meth-(Z)-ylidene]-amine

1-methyl-4-(2'-phenyl-3',4',5',6'-tetramethoxycarbonyl-1',2'-dihydropyridin-1'-yl)-2,3,6-triphenylpiperidine

Refernces

• 1、 Mobio,Soldatenkov,Fedorov,Ageev,Sergeeva,Lin,Stashenko,Prostakov,Andreeva,Minaev,Kol'tsova,Denisov,Kapitonenko,Ovodenko. "Synthesis and physiological activity of 2,3,6-triaryl-4-oxo[hydroxy, hydroxyimino, amino]piperidines". . p. 308 - 314. Retrieved 2007/10/02.