1-Methyl-2,3,6-triphenyl-4-piperidinone

Base Information

• Chemical Name: 1-Methyl-2,3,6-triphenyl-4-piperidinone
• CAS No.: 71864-80-7
• Molecular Formula: C₂₄H₂₃NO
• Molecular Weight: 341.453
• DSSTox Substance ID: DTXSID80992575
• Mol file: 71864-80-7.mol

Synonyms:BRN 1593267;1-Methyl-2,3,6-triphenyl-4-piperidinone;71864-80-7;4-Piperidinone, 1-methyl-2,3,6-triphenyl-;5-21-09-00354 (Beilstein Handbook Reference);C24H23NO;1-methyl-2,3,6-triphenylpiperidin-4-one;Oprea1_196826;Oprea1_678448;DTXSID80992575;C24-H23-N-O;1-methyl-2,3,6-triphenyl-4-piperidone;LS-117275

Chemical Property of 1-Methyl-2,3,6-triphenyl-4-piperidinone

Chemical Property:

• Vapor Pressure: 9.37E-10mmHg at 25°C
• Boiling Point: 490.2°C at 760 mmHg
• Flash Point: 235.2°C
• PSA: 20.31000
• Density: 1.113g/cm³
• LogP: 5.09530
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 341.177964357
• Heavy Atom Count: 26
• Complexity: 457

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(CC(=O)C(C1C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 1-Methyl-2,3,6-triphenyl-4-piperidinone

There total 2 articles about 1-Methyl-2,3,6-triphenyl-4-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + methylamine (74-89-5) + 1-phenyl-acetone (103-79-7,136675-26-8) → 1-methyl-2,3,6-triphenylpiperidin-4-one (71864-80-7)

Guidance literature:

In acetic acid; at 20 ℃; for 15h;

DOI:10.1007/BF00758420

Reference yield:

→ 1-methyl-2,3,6-triphenylpiperidin-4-one (71864-80-7)

Guidance literature:

Methylbenzylketon, Benzaldehyd, Me2NH, Eisessig;

DOI:10.1007/BF00509801

Reference yield: 44.0%

1-methyl-2,3,6-triphenylpiperidin-4-one (71864-80-7) → 4-hydroxy-2,3,6-triphenylpyridine

Guidance literature:

With manganese(IV) oxide; In toluene; Heating;

DOI:10.1023/A:1016099826188

upstream raw materials:

benzaldehyde

methylamine

1-phenyl-acetone

Downstream raw materials:

1-methyl-2,3,6-triphenyl-4-hydroxypiperidine

1,2,5-Triphenyl-1,4-pentadien-3-one

5-(N-Acetyl-N-methylamino)-1,2,5-triphenyl-1-penten-3-one

1-methyl-2,3,6-triphenyl-4-benzyl-4-hydroxypiperidine

Refernces