2,3,5,6-Tetrahydro-5-(4-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Base Information

Chemical Name:2,3,5,6-Tetrahydro-5-(4-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol
CAS No.:56882-42-9
Molecular Formula:C₁₇H₁₅ClN₂O
Molecular Weight:298.772
Hs Code.:
DSSTox Substance ID:DTXSID50972309
Nikkaji Number:J61.472F
ChEMBL ID:CHEMBL351948
Mol file:56882-42-9.mol

Synonyms:BRN 0757457;56882-42-9;2,3,5,6-Tetrahydro-5-(4-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol;Imidazo(2,1-a)isoquinolin-5-ol, 2,3,5,6-tetrahydro-5-(p-chlorophenyl)-;5-(4-Chlorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol;CHEMBL351948;SCHEMBL9693442;DTXSID50972309;LS-77909

Suppliers and Price of 2,3,5,6-Tetrahydro-5-(4-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2,3,5,6-Tetrahydro-5-(4-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

Chemical Property:

Vapor Pressure:2.32E-09mmHg at 25°C
Boiling Point:462.8°Cat760mmHg
Flash Point:233.7°C
PSA：35.83000
Density:1.35g/cm³
LogP:2.17710
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:298.0872908
Heavy Atom Count:21
Complexity:433

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN2C(=N1)C3=CC=CC=C3CC2(C4=CC=C(C=C4)Cl)O

Technology Process of 2,3,5,6-Tetrahydro-5-(4-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol

There total 4 articles about 2,3,5,6-Tetrahydro-5-(4-chlorophenyl)-imidazo(2,1-a)isoquinolin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 56882-42-9
5-(4-chloro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: benzene; methanol / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; In methanol; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 74-11-3
para-chlorobenzoic acid

: 56882-42-9
5-(4-chloro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 5 h / Heating

2: benzene; methanol / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; thionyl chloride; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 1126-46-1
Methyl 4-chlorobenzoate

: 57327-93-2
2-(o-Tolyl)-2-imidazoline

: 56882-42-9
5-(4-chloro-phenyl)-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 35 deg C, 4 h, 2.) -20 deg C, 6 h;
DOI:10.1021/jo00147a027