Technology Process of 1-Piperidinecarboxylic acid,
4-[3-[4-[4-diazo-3-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]phenoxy
]propyl]-, 1,1-dimethylethyl ester, (S)-
There total 5 articles about 1-Piperidinecarboxylic acid,
4-[3-[4-[4-diazo-3-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]phenoxy
]propyl]-, 1,1-dimethylethyl ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / H2 / 10percent Pd/C / acetic acid / 48 h / 2585.7 Torr
2: 73 percent / NaOH / dioxane / 18 h
3: 78 percent / imidazol, I2, triphenylphosphine chloride / toluene / 1.5 h
4: 27 percent / cesium carbonate / dimethylformamide / 20 h / Ambient temperature
5: 100 percent / NaOH / methanol / 16 h
6: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) EtOAc, -15 deg C, 0.5 h, 2.) EtOAc, Et2O, 0 deg C, 20 min
With
4-methyl-morpholine; 1H-imidazole; sodium hydroxide; hydrogen; iodine; caesium carbonate; dichlorotriphenylphosphorane; isobutyl chloroformate;
palladium on activated charcoal;
In
1,4-dioxane; methanol; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00042a007
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 73 percent / NaOH / dioxane / 18 h
2: 78 percent / imidazol, I2, triphenylphosphine chloride / toluene / 1.5 h
3: 27 percent / cesium carbonate / dimethylformamide / 20 h / Ambient temperature
4: 100 percent / NaOH / methanol / 16 h
5: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) EtOAc, -15 deg C, 0.5 h, 2.) EtOAc, Et2O, 0 deg C, 20 min
With
4-methyl-morpholine; 1H-imidazole; sodium hydroxide; iodine; caesium carbonate; dichlorotriphenylphosphorane; isobutyl chloroformate;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00042a007
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 78 percent / imidazol, I2, triphenylphosphine chloride / toluene / 1.5 h
2: 27 percent / cesium carbonate / dimethylformamide / 20 h / Ambient temperature
3: 100 percent / NaOH / methanol / 16 h
4: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) EtOAc, -15 deg C, 0.5 h, 2.) EtOAc, Et2O, 0 deg C, 20 min
With
4-methyl-morpholine; 1H-imidazole; sodium hydroxide; iodine; caesium carbonate; dichlorotriphenylphosphorane; isobutyl chloroformate;
In
methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00042a007
