2,4-Thiazolidinedione, 5-benzylidene-

Base Information

• Chemical Name: 2,4-Thiazolidinedione, 5-benzylidene-
• CAS No.: 3774-99-0
• Molecular Formula: C10H7NO2S
• Molecular Weight: 205.237
• Wikidata: Q76119878
• Mol file: 3774-99-0.mol

Synonyms:2,4-Thiazolidinedione, 5-benzylidene-;BRN 0139830;5-Benzylidenethiazolidene-2,4-dione;5-benzylidenethiazolidine-2,4-dione;(5E)-5-(phenylmethylidene)-1,3-thiazolidine-2,4-dione;3774-99-0;4-27-00-03368 (Beilstein Handbook Reference);74942-47-5;2,4-Thiazolidinedione, 5-(phenylmethylene)-;(5E)-5-benzylidene-1,3-thiazolidine-2,4-dione;HMS1367N05;MFCD00522528;STL293366;(e)-benzylidenethiazolidine-2,4-dione;AKOS001028727;5-benzylidene-1,3-thiazolane-2,4-dione;(5E)-5-benzylidenethiazolidine-2,4-dione;LS-151290;CS-0067867;8T-0084;5-[(E)-phenylmethylidene]-1,3-thiazolane-2,4-dione

Chemical Property of 2,4-Thiazolidinedione, 5-benzylidene-

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 74.96000
• Density: 1.415g/cm³
• LogP: 2.28640
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 205.01974964
• Heavy Atom Count: 14
• Complexity: 293

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=C2C(=O)NC(=O)S2
• Isomeric SMILES: C1=CC=C(C=C1)/C=C/2\C(=O)NC(=O)S2

Technology Process of 2,4-Thiazolidinedione, 5-benzylidene-

There total 44 articles about 2,4-Thiazolidinedione, 5-benzylidene- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

thiazoline-2,4-dione (2295-31-0) + benzaldehyde (100-52-7) → 5-benzylidene-2,4-thiazolidinedione (3774-99-0)

Guidance literature:

With thiourea; urea; at 110 ℃; for 0.0833333h; Neat (no solvent);

DOI:10.1016/j.bmcl.2012.07.049

Reference yield: 97.0%

thiazoline-2,4-dione (2295-31-0) + benzaldehyde (100-52-7) → (Z)-5-benzylidene-1,3-thiazolidine-2,4-dione (3774-99-0,74942-47-5,74942-62-4)

Guidance literature:

With Fe₃O₄/SiO₂-NH₂/Cu(II); In ethanol; for 0.5h; Concentration; Time; Solvent; Mechanism; Catalytic behavior; Reflux; Green chemistry;

DOI:10.1007/s11243-017-0159-3

Reference yield: 81.0%

thiazoline-2,4-dione (2295-31-0) + sodium hydroxy(phenyl)methanesulfonate (4657-12-9) → (Z)-5-benzylidene-1,3-thiazolidine-2,4-dione (3774-99-0,74942-47-5,74942-62-4)

Guidance literature:

With trichlorophosphate; In toluene; for 8h; Reflux;

DOI:10.2174/15701786113106660081

upstream raw materials:

thiazoline-2,4-dione

benzaldehyde

acetic acid

2-anilino-5-benzylidene-thiazol-4-one

Downstream raw materials:

3-hydroxymethyl-5-benzylidene-2,4-thiazolidinedione

6-benzyl-2-phenyl-3-phenylazo-1,2,4-triazin-5(2H)-one

6-benzyl-2-phenyl-3-phenylhydrazino-1,2,4-triazin-5(2H)-one

5-(Benzyl)thiazolidine-2,4-dione