Hexanoic acid, 6-[[5-methyl-3-(3-phenylpropyl)-2-thienyl]thio]-

Base Information

• Chemical Name: Hexanoic acid, 6-[[5-methyl-3-(3-phenylpropyl)-2-thienyl]thio]-
• CAS No.: 142422-76-2
• Molecular Formula: C₂₀H₂₆O₂S₂
• Molecular Weight: 362.557
• Mol file: 142422-76-2.mol

Synonyms:

Chemical Property of Hexanoic acid, 6-[[5-methyl-3-(3-phenylpropyl)-2-thienyl]thio]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hexanoic acid, 6-[[5-methyl-3-(3-phenylpropyl)-2-thienyl]thio]-

There total 8 articles about Hexanoic acid, 6-[[5-methyl-3-(3-phenylpropyl)-2-thienyl]thio]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-[5-Methyl-3-(3-phenyl-propyl)-thiophen-2-ylsulfanyl]-hexanoic acid ethyl ester (142423-07-2) → 6-<<5-methyl-3-(3-phenylpropyl)-2-thienyl>thio>hexanoic acid (142422-76-2)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Yield given; Heating;

DOI:10.1021/jm00095a011

Reference yield:

2-methyl-4-thiophenecarboxaldehyde (29421-72-5) → 6-<<5-methyl-3-(3-phenylpropyl)-2-thienyl>thio>hexanoic acid (142422-76-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) Mg / 1.) THF, 0 deg C, 2.) THF, reflux, 1 h

2: pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 1 h / Ambient temperature

3: H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

4: 1.) n-BuLi, 2.) sulfur / 1.) diethyl ether, hexane, 0 deg C, 15 min, 2.) diethyl ether, hexane, 25 deg C, 30 min

5: 2.2 g / hexane; diethyl ether / 16 h / 25 °C

6: NaOH / ethanol / 2 h / Heating

With potassium hydroxide; sodium hydroxide; n-butyllithium; sodium acetate; sulfur; hydrazine hydrate; magnesium; pyridinium chlorochromate; In diethyl ether; ethanol; hexane; dichloromethane;

DOI:10.1021/jm00095a011

Reference yield:

6-bromo-hexanoic acid ethyl ester (25542-62-5) → 6-<<5-methyl-3-(3-phenylpropyl)-2-thienyl>thio>hexanoic acid (142422-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.2 g / hexane; diethyl ether / 16 h / 25 °C

2: NaOH / ethanol / 2 h / Heating

With sodium hydroxide; In diethyl ether; ethanol; hexane;

DOI:10.1021/jm00095a011

upstream raw materials:

6-[5-Methyl-3-(3-phenyl-propyl)-thiophen-2-ylsulfanyl]-hexanoic acid ethyl ester

2-methyl-4-thiophenecarboxaldehyde

6-bromo-hexanoic acid ethyl ester

1-phenyl-2-bromoethane