4,5,6,7-TETRAHYDRO-2-BENZOTHIOPHENE-1-CARBOXYLIC ACID

Base Information

• Chemical Name: 4,5,6,7-TETRAHYDRO-2-BENZOTHIOPHENE-1-CARBOXYLIC ACID
• CAS No.: 6435-75-2
• Molecular Formula: C9H10 O2 S
• Molecular Weight: 182.24
• Hs Code.: 2934999090
• Mol file: 6435-75-2.mol

Synonyms:4,5,6,7-Tetrahydrobenzo[c]thiophene-1-carboxylicacid; NSC 172280

Chemical Property of 4,5,6,7-TETRAHYDRO-2-BENZOTHIOPHENE-1-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.97E-06mmHg at 25°C
• Melting Point: 203 °C
• Boiling Point: 394.5°C at 760 mmHg
• Flash Point: 155.5°C
• PSA: 65.54000
• Density: 1.243g/cm³
• LogP: 2.32510
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,5,6,7-Tetrahydrobenzo[c]thiophene-1-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5,6,7-TETRAHYDRO-2-BENZOTHIOPHENE-1-CARBOXYLIC ACID

There total 1 articles about 4,5,6,7-TETRAHYDRO-2-BENZOTHIOPHENE-1-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid (6435-75-2)

Guidance literature:

1-Methoxycarbonyl-4.5.6.7-tetrahydro-benzothiophen, wss. Ba(OH)2 (Siedetemp., 3 Std.);

Reference yield: 87.0%

4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid (6435-75-2) + {2‐azabicyclo[2.1.1]hexan‐1‐yl}methanamine → N‐({2‐benzyl‐2‐azabicyclo[2.1.1]hexan‐1‐yl}methyl)‐4,5,6,7‐tetrahydro‐2‐benzothiophene‐1‐carboxamide

Guidance literature:

4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid; With 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

{2‐azabicyclo[2.1.1]hexan‐1‐yl}methanamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/acsmedchemlett.0c00486

Reference yield: 34.0%

4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid (6435-75-2) + ethyl iodide (75-03-6) → 3-ethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid (1516885-78-1)

Guidance literature:

4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.166667h;

ethyl iodide; In tetrahydrofuran; pentane; at -78 ℃; for 3h;

DOI:10.1021/jm401456d

Downstream raw materials:

3-ethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid

(S)-3-(4-(2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1-(3-ethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)propan-1-one

N-((S)-3-{2-ethyl-4-[5-(3-ethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-1-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide