6-Hydroxygalangin

Base Information

Chemical Name:6-Hydroxygalangin
CAS No.:142646-44-4
Molecular Formula:C15H10O6
Molecular Weight:286.241
Hs Code.:
DSSTox Substance ID:DTXSID30570342
Metabolomics Workbench ID:25885
Nikkaji Number:J489.733A
Wikidata:Q82457752

Synonyms:6-Hydroxygalangin;142646-44-4;3,5,6,7-tetrahydroxy-2-phenyl-4H-chromen-4-one;tetrahydroxyflavone;SCHEMBL157972;DTXSID30570342;LMPK12112802;3,5,6,7-Tetrahydroxy-2-phenyl-4H-1-benzopyran-4-one

Suppliers and Price of 6-Hydroxygalangin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 6-Hydroxygalangin

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:286.04773803
Heavy Atom Count:21
Complexity:453

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C=C(C(=C3O)O)O)O

Technology Process of 6-Hydroxygalangin

There total 13 articles about 6-Hydroxygalangin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 103393-09-5
3-hydroxy-5,6,7-trimethoxy-2-phenyl-4H-benzopyran-4-one

: 142646-44-4
3,5,6,7-tetrahydroxy-2-phenyl-4H-chromen-4-one

Guidance literature:: With boron tribromide; In dichloromethane; at -80 - 20 ℃; for 13h;
DOI:10.1016/j.bmc.2004.12.010

Reference yield:

: 6962-57-8
3,6-dihydroxy-2,4-dimethoxyacetophenone

: 142646-44-4
3,5,6,7-tetrahydroxy-2-phenyl-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: i-Pr₂NEt / CH₂Cl₂

2: pyridine / 50 - 60 °C

3: KOH, pyridine / 80 °C

4: 88 percent / conc. H₂SO₄, AcOH / 60 °C

5: 85 percent / i-Pr₂NEt / CH₂Cl₂ / Ambient temperature

6: 1.) dimethyldioxirane, 2.) TsOH / 1.) CH₂Cl₂, Me₂CO, 0 deg C, 2.) CH₂Cl₂, 0 deg C, 0.5 h

7: 90 percent / conc. HCl, HOAc / 0.5 h / Ambient temperature

8: 1.) AlCl₃, NaI, 2.) 3percent aq. HCl, Na₂SO₃ / 1.) MeCN, 30 deg C, 5 h, 2.) MeCN, from 60 to 70 deg C, 30 min

With pyridine; hydrogenchloride; potassium hydroxide; aluminium trichloride; sulfuric acid; 3,3-dimethyldioxirane; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium sulfite; In dichloromethane;
DOI:10.1246/bcsj.68.2033

Reference yield:

: 119892-40-9
6-hydroxy-5,7-dimethoxyflavone

: 142646-44-4
3,5,6,7-tetrahydroxy-2-phenyl-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / i-Pr₂NEt / CH₂Cl₂ / Ambient temperature

2: 1.) dimethyldioxirane, 2.) TsOH / 1.) CH₂Cl₂, Me₂CO, 0 deg C, 2.) CH₂Cl₂, 0 deg C, 0.5 h

3: 90 percent / conc. HCl, HOAc / 0.5 h / Ambient temperature

4: 1.) AlCl₃, NaI, 2.) 3percent aq. HCl, Na₂SO₃ / 1.) MeCN, 30 deg C, 5 h, 2.) MeCN, from 60 to 70 deg C, 30 min

With hydrogenchloride; aluminium trichloride; 3,3-dimethyldioxirane; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium sulfite; In dichloromethane;
DOI:10.1246/bcsj.68.2033