3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE

Base Information

• Chemical Name: 3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE
• CAS No.: 6962-57-8
• Molecular Formula: C10H12O5
• Molecular Weight: 212.202
• Hs Code.: 2914509090
• Mol file: 6962-57-8.mol

Synonyms:Acetophenone,3',6'-dihydroxy-2',4'-dimethoxy- (6CI,7CI,8CI);3',6'-Dihydroxy-2',4'-dimethoxyacetophenone;NSC 37417;

Chemical Property of 3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE

Chemical Property:

• Vapor Pressure: 7.77E-08mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 425.4 °C at 760 mmHg
• Flash Point: 171.2 °C
• PSA: 75.99000
• Density: 1.279 g/cm³
• LogP: 1.31760

Purity/Quality:

98% ^*data from raw suppliers

3,6-Dihydroxy-2,4-dimethoxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE

There total 16 articles about 3,6-DIHYDROXY-2,4-DIMETHOXYACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,6-dimethoxy-1,4-hydroquinone (15233-65-5) + acetic anhydride (108-24-7) → 3,6-dihydroxy-2,4-dimethoxyacetophenone (6962-57-8)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,2-dichloro-ethane; at 20 - 80 ℃;

DOI:10.3184/174751917X14873588907765

Reference yield: 82.0%

2-hydroxy-4,6-dimethoxyacetophenone (90-24-4) → 2,30dihydroxy-4,6-dimethoxyacetophenone (21919-66-4) + 3,6-dihydroxy-2,4-dimethoxyacetophenone (6962-57-8)

Guidance literature:

With 3,3-dimethyldioxirane; In dichloromethane; acetone; at 0 - 20 ℃; for 0.166667h;

DOI:10.1016/j.tet.2004.01.023

Reference yield: 70.0%

4-(acetyloxy)-3,5-dimethoxyphenyl acetate (7702-17-2) → 3,6-dihydroxy-2,4-dimethoxyacetophenone (6962-57-8)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; at 110 ℃; for 18h; Temperature;

upstream raw materials:

2-hydroxy-4,6-dimethoxyacetophenone

4-(acetyloxy)-3,5-dimethoxyphenyl acetate

3,4,5-trimethoxyphenol

acetyl chloride

Downstream raw materials:

6-hydroxy-5,7-dimethoxyflavone

1-(3-Dodecyloxy-6-hydroxy-2,4-dimethoxy-phenyl)-ethanone

1-(3-Hexadecyloxy-6-hydroxy-2,4-dimethoxy-phenyl)-ethanone

1-(6-hydroxy-2,4-dimethoxy-3-methoxymethoxyphenyl)-ethanone

Refernces

• 1、 Wang, Qian,Liao, Xia-Li,Xiang, Cheng,Yang, Jian. "A practical synthesis of the flavone, scutellarein". . p. 157 - 159. Retrieved 2017/03/27.
• 2、 -. "Method for preparing scutellarin". Paragraph 0013. . Retrieved 2017/01/02.