[4-(1,3-Dioxolan-2-yl)phenyl]methanol

Base Information

• Chemical Name: [4-(1,3-Dioxolan-2-yl)phenyl]methanol
• CAS No.: 142651-25-0
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• DSSTox Substance ID: DTXSID60569880
• Wikidata: Q82457130
• Mol file: 142651-25-0.mol

Synonyms:142651-25-0;[4-(1,3-Dioxolan-2-yl)phenyl]methanol;Benzenemethanol, 4-(1,3-dioxolan-2-yl)-;(4-(1,3-Dioxolan-2-yl)phenyl)methanol;SCHEMBL2202537;DTXSID60569880;OSSSEXIGKVKXPO-UHFFFAOYSA-N;A1-12043

Chemical Property of [4-(1,3-Dioxolan-2-yl)phenyl]methanol

Chemical Property:

• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(O1)C2=CC=C(C=C2)CO

Technology Process of [4-(1,3-Dioxolan-2-yl)phenyl]methanol

There total 6 articles about [4-(1,3-Dioxolan-2-yl)phenyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

4-(1,3-dioxolan-2-yl)benzaldehyde (40681-88-7) → 4-(1',3'-dioxolan-2'-yl)benzyl alcohol (142651-25-0)

Guidance literature:

With sodium tetrahydroborate; water;

Reference yield: 83.2%

ethylene glycol (107-21-1) + methyl 4-formylbenzoate (1571-08-0) → 4-(1',3'-dioxolan-2'-yl)benzyl alcohol (142651-25-0)

Guidance literature:

ethylene glycol; methyl 4-formylbenzoate; With toluene-4-sulfonic acid; In toluene; for 1h; Dean-Stark conditions;

With sodium dihydro-bis-(2-methoxyethoxy)aluminate; In toluene; at 22 ℃;

With water; Rochelle's salt; In toluene; for 1h;

Reference yield: 82.0%

methyl 4-(1,3-dioxolan-2-yl)benzoate (142651-24-9) → 4-(1',3'-dioxolan-2'-yl)benzyl alcohol (142651-25-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

upstream raw materials:

methyl 4-(1,3-dioxolan-2-yl)benzoate

4-(1,3-dioxolan-2-yl)benzaldehyde

methyl 4-formylbenzoate

ethylene glycol

Downstream raw materials:

1-<<<4-(1,3-Dioxolan-2-yl)>benzyl>oxy>-2-benzyl-9,10-anthraquinone

4-(bromomethyl)benzaldehyde

3,5-bis(4-formylbenzyloxy)benzyl alcohol

2-(4-(chloromethyl)phenyl)-1,3-dioxolane