Tris(morpholino)phosphine

Base Information

• Chemical Name: Tris(morpholino)phosphine
• CAS No.: 5815-61-2
• Molecular Formula: C12H24 N3 O3 P
• Molecular Weight: 289.315
• NSC Number: 92800
• DSSTox Substance ID: DTXSID60293890
• Nikkaji Number: J3.178.213I
• Wikidata: Q82032887
• Mol file: 5815-61-2.mol

Synonyms:Tris(morpholino)phosphine;5815-61-2;trimorpholin-4-ylphosphane;tris(4-morpholino)phosphine;Trimorpholinophosphine;4-[bis(morpholin-4-yl)phosphanyl]morpholine;NSC92800;Morpholine,4,4',4''-phosphinidynetris-;trimorpholinophosphane;Morpholine, 4,4',4''-phosphinidynetris-;Tri-4-morpholinylphosphine;Oprea1_053761;SCHEMBL2227302;C12H24N3O3P;DTXSID60293890;CYABZYIVQJYRDT-UHFFFAOYSA-N;MFCD00014617;NSC-92800;AKOS003618531;Morpholine,4',4''-phosphinidynetris-;4-[Di(4-morpholinyl)phosphino]morpholine;4-[Di(4-morpholinyl)phosphino]morpholine #;FT-0756737

Chemical Property of Tris(morpholino)phosphine

Chemical Property:

• Melting Point: 157°C
• Boiling Point: 401.8±45.0 °C(Predicted)
• PKA: 8.99±0.20(Predicted)
• PSA: 51.00000
• Density: 1.34g/cm³
• LogP: 0.02360
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 289.15552863
• Heavy Atom Count: 19
• Complexity: 224

Purity/Quality:

4-[bis(Morpholin-4-yl)phosphanyl]morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1P(N2CCOCC2)N3CCOCC3

Technology Process of Tris(morpholino)phosphine

There total 9 articles about Tris(morpholino)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + hexaethylphosphoric triamide (2283-11-6) → tris(morpholino)phosphine (5815-61-2)

Guidance literature:

at 70 ℃; for 10h; var. time and temp.;

DOI:10.1016/S0040-4039(00)82246-7

Reference yield: 98.0%

trimorpholylmethane (22630-09-7) + dimorpholinophosphinous chloride (75302-66-8) → tris(morpholino)phosphine (5815-61-2)

Guidance literature:

With phosphorus trichloride;

Reference yield: 44.0%

morpholine (110-91-8,99108-56-2) → tris(morpholino)phosphine (5815-61-2)

Guidance literature:

With phosphorus trichloride; 1) ice-water bath, CHCl₃, 2) reflux, 1.5 h;

DOI:10.1021/jo01313a026

upstream raw materials:

morpholine

hexaethylphosphoric triamide

4-(trimethylsilyl)morpholine

bis(diethylamino)chlorophosphine

Downstream raw materials:

benzaldehyde (tri-morpholin-4-yl-λ⁵-phosphanylidene)-hydrazone

Benzyl-trimorpholinophosphoniumbromid

(4-hydroxy-phenyldiazenyl)-tri-morpholin-4-yl-phosphonium betaine

Dichlormethyl-trimorpholinophosphonium