5-Benzofuranacetic acid, ethyl ester

Base Information

• Chemical Name: 5-Benzofuranacetic acid, ethyl ester
• CAS No.: 142935-51-1
• Molecular Formula: C12H12O3
• Molecular Weight: 204.22200
• Hs Code.: 2932990090
• Mol file: 142935-51-1.mol

Synonyms:

Chemical Property of 5-Benzofuranacetic acid, ethyl ester

Chemical Property:

• PSA: 39.44000
• LogP: 2.53840

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(benzofuran-5-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Benzofuranacetic acid, ethyl ester

There total 3 articles about 5-Benzofuranacetic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

5-bromobenzofuran (23145-07-5) + diethyl malonate (105-53-3) → ethyl 2-(benzofuran-5-yl)acetate (142935-51-1)

Guidance literature:

With C₁₉H₂₃N₃O₂; copper(l) chloride; sodium t-butanolate; In ethanol; at 80 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.1c03688

Reference yield: 26.0%

ethyl 2-(4-(2,2-diethoxyethoxy)phenyl)acetate (142935-50-0) → ethyl 2-(benzofuran-5-yl)acetate (142935-51-1)

Guidance literature:

With PPA; In toluene; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

(4-hydroxy-phenyl)-acetic acid ethyl ester (17138-28-2) → ethyl 2-(benzofuran-5-yl)acetate (142935-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 100 °C

2: PPA / toluene / 3 h / 80 °C / Inert atmosphere

With potassium carbonate; In N,N-dimethyl-formamide; toluene;

upstream raw materials:

ethyl 2-(4-(2,2-diethoxyethoxy)phenyl)acetate

5-bromobenzofuran

diethyl malonate

(4-hydroxy-phenyl)-acetic acid ethyl ester

Downstream raw materials:

benzofuran-5-yl-acetic acid

Refernces

• 1、 -. "ADVANTAGEOUS BENZOFURAN COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT". Page/Page column 274; 275; 288; 289. . Retrieved 2021/12/31.