2-(Benzofuran-5-yl)acetic Acid

Base Information

• Chemical Name: 2-(Benzofuran-5-yl)acetic Acid
• CAS No.: 142935-60-2
• Molecular Formula: C10H8O3
• Molecular Weight: 176.172
• Hs Code.: 2932990090
• Mol file: 142935-60-2.mol

Synonyms:2-(Benzofuran-5-yl)acetic Acid;Benzofuran-5-yl-Acetic Acid;5-Benzofuranacetic acid

Chemical Property of 2-(Benzofuran-5-yl)acetic Acid

Chemical Property:

• Boiling Point: 331.1±17.0 °C(Predicted)
• PKA: 4.22±0.30(Predicted)
• PSA: 50.44000
• Density: 1.316±0.06 g/cm3(Predicted)
• LogP: 2.05990
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-BenzofuranaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Benzofuranacetic Acid is a reactant used in the preparation of α2-antagonist/5-HT uptake inhibitors as an antidepressant (1).

Technology Process of 2-(Benzofuran-5-yl)acetic Acid

There total 12 articles about 2-(Benzofuran-5-yl)acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-(benzofuran-5-yl)acetate (142935-51-1) → benzofuran-5-yl-acetic acid (142935-60-2)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield: 59.1%

methyl 2-(benzofuran-5-yl)acetate (121638-36-6) → benzofuran-5-yl-acetic acid (142935-60-2)

Guidance literature:

With water; sodium hydroxide; In methanol; at 25 - 30 ℃;

Reference yield: 44.0%

2,3-dihydrobenzofuran-5-acetic acid (69999-16-2) → benzofuran-5-yl-acetic acid (142935-60-2)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 0 ℃; for 3h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

2,3-dihydrobenzofuran-5-acetic acid

1-bromo-2,2-dimethoxyethane

4-hydroxyphenylacetate

methyl 2-(benzofuran-5-yl)acetate

Downstream raw materials:

2,3-dihydrobenzofuran-5-acetic acid

5-(2-hydroxyethyl)-2,3-dihydrobenzofuran

2,3-dihydro-5-(2-bromoethyl)benzofuran

methyl 2-(benzofuran-5-yl)acetate