Ranelic acid

Base Information

Chemical Name:Ranelic acid
CAS No.:135459-90-4
Molecular Formula:C₁₂H₁₀N₂O₈S
Molecular Weight:342.286
Hs Code.:2934999090
European Community (EC) Number:690-882-9
UNII:K9CCS0RIBT
DSSTox Substance ID:DTXSID3048237
Nikkaji Number:J2.940.010E
Wikipedia:Ranelic_acid,Strontium_ranelate
Wikidata:Q410646
NCI Thesaurus Code:C76602
ChEMBL ID:CHEMBL2107175
Mol file:135459-90-4.mol

Synonyms:Ranelic acid;135459-90-4;Ranelic acid [INN];Strontiumranelate;K9CCS0RIBT;UNII-K9CCS0RIBT;Protelos/Osseor;Ranelic acid (INN);Strontium ranelate;2,2'-((5-Carboxy-4-(carboxymethyl)-3-cyanothiophen-2-yl)azanediyl)diacetic acid;135459-87-9;C12-H10-N2-O8-S.2Sr;5-(Bis(carboxymethyl)amino)-2-carboxy-4-cyano-3-thiopheneacetic acid;5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid;RANELIC ACID [MI];5-[bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid;SCHEMBL500994;RANELIC ACID [WHO-DD];CHEMBL2107175;DTXSID3048237;C12H10N2O8S;5-[bis-(Carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid;C12-H10-N2-O8-S;FT-0701838;D08467;Q410646;5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyanothiophene-3-acetic acid;2-[n,n-di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid

Suppliers and Price of Ranelic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RanelicAcid
500mg
$ 1190.00

TRC
RanelicAcid
50mg
$ 150.00

Medical Isotopes, Inc.
RanelicAcid
500 mg
$ 2200.00

Medical Isotopes, Inc.
RanelicAcid
50 mg
$ 650.00

Total 14 raw suppliers

Chemical Property of Ranelic acid

Chemical Property:

Vapor Pressure:1.57E-25mmHg at 25°C
Boiling Point:778.8 °C at 760 mmHg
Flash Point:424.8 °C
PSA：204.47000
Density:1.81 g/cm³
LogP:-0.07932
XLogP3:0.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:8
Exact Mass:342.01578646
Heavy Atom Count:23
Complexity:555

Purity/Quality:

99% ^*data from raw suppliers

RanelicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(C1=C(SC(=C1C#N)N(CC(=O)O)CC(=O)O)C(=O)O)C(=O)O
Recent EU Clinical Trials:A double-blind, multicenter, international randomised study to assess the effects of 4 month-oral administration of 2g per day of strontium ranelate versus placebo on the bone quality and remodelling, as assessed on an alveolar bone biopsy extracted before dental implantation, in osteoporotic patients or in patients at risk of osteoporotic fracture.
Uses Ranelic Acid, is an organic acid used as metal cations chelating agent. The strontium salt of Ranelic Acid (S687700), is used as bone metabolism modulator, that inhibits bone resorption while maintaining bone formation. Antiosteoporotic.

Technology Process of Ranelic acid

There total 1 articles about Ranelic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 674800-87-4
5-[bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic acid methyl ester

: 135459-90-4
ranelic acid

Guidance literature:: 5-[bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic acid methyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 5 - 10 ℃; for 22h;

With sulfuric acid; pH=> 1;