5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic Acid Methyl Ester

Base Information

Chemical Name:5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic Acid Methyl Ester
CAS No.:674800-87-4
Molecular Formula:C18H22N2O8S
Molecular Weight:426.44
Hs Code.:
Mol file:674800-87-4.mol

Synonyms:methyl 5-[bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-3-(2-methoxy-2-oxoethyl)-2-thiophenecarboxylate;methyl 5-[bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-3-(2-methoxy-2-oxoethyl)-2-thiophene-carboxylate;

Suppliers and Price of 5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic Acid Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneaceticAcidMethylEster
250mg
$ 1320.00

Medical Isotopes, Inc.
5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneaceticAcidMethylEster
250 mg
$ 2200.00

Total 3 raw suppliers

Chemical Property of 5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic Acid Methyl Ester

Chemical Property:

PSA：160.47000
LogP:1.05448
Storage Temp.:-20°C Freezer
Solubility.:Dichloromethane, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneaceticAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic Acid Methyl Ester is an intermediate used in the preparation of Strontium Ranelate (S687700).

Technology Process of 5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic Acid Methyl Ester

There total 4 articles about 5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 674773-14-9
5-amino-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid

: 96-32-2
bromoacetic acid methyl ester

: 674800-87-4
5-[bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic acid methyl ester

Guidance literature:: With potassium carbonate; Adogen 464; In acetone; at 60 ℃; for 5h; Heating / reflux;

Reference yield:

: 674773-12-7
methyl 5-amino-4-cyano-3-(2-methoxy-2-oxoethyl)-2-thiophene-carboxylate

: 105-36-2
ethyl bromoacetate

: 674800-87-4
5-[bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic acid methyl ester

Guidance literature:: With potassium carbonate; potassium iodide; In dimethyl sulfoxide; acetone; at 20 - 40 ℃; for 7h; Product distribution / selectivity;

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 674800-87-4
5-[bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / methanol / 40 - 45 °C

1.2: Reflux

2.1: potassium carbonate; potassium iodide / acetonitrile; dimethyl sulfoxide / 7 h / 35 - 40 °C

With 1H-imidazole; potassium carbonate; potassium iodide; In methanol; dimethyl sulfoxide; acetonitrile;