674800-87-4

Usage

Uses

Used in Pharmaceutical Industry:
5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic Acid Methyl Ester is used as an intermediate in the synthesis of Strontium Ranelate (S687700) for the treatment of various medical conditions. Strontium Ranelate is a drug that combines the properties of a bisphosphonate and a strontium salt, making it effective in treating osteoporosis and other bone-related disorders. 5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(methoxycarbonyl)-3-thiopheneacetic Acid Methyl Ester's unique structure allows it to play a crucial role in the formation of the final drug product, contributing to its therapeutic effects.

Upstream product

• 674773-14-9 5-amino-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid 
• 96-32-2 bromoacetic acid methyl ester 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 674773-12-7 methyl 5-amino-4-cyano-3-(2-methoxy-2-oxoethyl)-2-thiophene-carboxylate 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 135459-90-4 ranelic acid 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE

The present invention relates to an improved process for the synthesis of strontium ranelate or hydrates thereof. More particularly, the present invention relates to an effective process for the preparation of a compound of formula III, which is a useful intermediate in the synthesis of strontium ranelate. wherein R1 and R2 represents substituted or unsubstituted linear or branched C1-C6 alkyl group or C3-C12 cyclic group.

A PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE

The present invention relates to an improved process for the synthesis of strontium ranelate or hydrates thereof. More particularly, the present invention relates to an effective process for the preparation of a compound of formula (III), which is a useful intermediate in the synthesis of strontium ranelate wherein R1 and R2 represents substituted or unsubstituted linear or branched C1-C6 alkyl group or C3-C12 cyclic group.

Process for the industrial synthesis of strontium ranelate and its hydrates

Process for the industrial synthesis of strontium ranelate of formula (I): and its hydrates.

Process for the industrial synthesis of tetraesters of 5-[BIS(CARBOXYMETHYL)AMINO]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates

Process for the industrial synthesis of compounds of formula (I): wherein R and R′ which are the same or different, each represent linear or branched (C1-C6)alkyl. Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.