Benzoic acid, 5-chloro-2-methyl-4-nitro-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 5-chloro-2-methyl-4-nitro-, methyl ester
• CAS No.: 143034-83-7
• Molecular Formula: C9H8ClNO4
• Molecular Weight: 229.62
• Mol file: 143034-83-7.mol

Synonyms:

Chemical Property of Benzoic acid, 5-chloro-2-methyl-4-nitro-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 5-chloro-2-methyl-4-nitro-, methyl ester

There total 4 articles about Benzoic acid, 5-chloro-2-methyl-4-nitro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 5-chloro-2-methyl-4-nitrobenzoic acid (1401423-30-0) → methyl 5-chloro-2-methyl-4-nitro-benzoate (143034-83-7)

Guidance literature:

With thionyl chloride; at 0 - 70 ℃; for 16h; Inert atmosphere;

Reference yield:

5-chloro-2-methyl-4-nitroaniline (13852-51-2) → methyl 5-chloro-2-methyl-4-nitro-benzoate (143034-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / acetone; water / 0.5 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: acetic acid; sulfuric acid; water / 5 h / 120 °C

3.1: thionyl chloride / 5 h / Reflux

With hydrogenchloride; thionyl chloride; sulfuric acid; water; acetic acid; sodium nitrite; In water; acetone;

Reference yield:

1-chloro-5-iodo-4-methyl-2-nitrobenzene (83706-53-0) → methyl 5-chloro-2-methyl-4-nitro-benzoate (143034-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 50 °C / Inert atmosphere

2: sulfuric acid; water; acetic acid / 16 h / 120 °C / Inert atmosphere

3: thionyl chloride / 16 h / 0 - 70 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sulfuric acid; water; sodium carbonate; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

methanol

5-chloro-2-methyl-4-nitrobenzoic acid

5-chloro-2-methyl-4-nitrobenzonitrile

5-chloro-2-methyl-4-nitroaniline

Downstream raw materials:

methyl 2-(bromomethyl)-5-chloro-4-nitrobenzoate

methyl 4-amino-5-chloro-2-methylbenzoate