2-Methoxypyrimidine-5-carbaldehyde

Base Information

• Chemical Name: 2-Methoxypyrimidine-5-carbaldehyde
• CAS No.: 90905-32-1
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 2933599090
• European Community (EC) Number: 815-062-1
• DSSTox Substance ID: DTXSID30389971
• Nikkaji Number: J433.188E
• Wikidata: Q72485872
• Mol file: 90905-32-1.mol

Synonyms:2-Methoxypyrimidine-5-carbaldehyde;90905-32-1;2-Methoxy-pyrimidine-5-carbaldehyde;5-FORMYL-2-METHOXYPYRIMIDINE;2-METHOXY-5-PYRIMIDINECARBALDEHYDE;5-PYRIMIDINECARBOXALDEHYDE, 2-METHOXY-;2-Methoxypyrimidine-5-carboxaldehyde;MFCD03446732;SCHEMBL1133947;DTXSID30389971;MERUNNHMVZFFRE-UHFFFAOYSA-N;STK731765;2-Methoxy-pyrimidine-5-carboxaldehyde;AKOS000283889;AB15446;AC-5039;CS-W003085;PS-4524;3-QUINOLINEBORONICACIDHYDROCHLORIDE;SY022439;AM20120310;BB 0262331;FT-0646816;EN300-75114;2-methoxypyrimidine-5-carbaldehyde, AldrichCPR;W-204044;Z274574980;2-methoxypy2-Methoxypyrimidine-5-carbaldehyderimidine-5-carbaldehyde

Chemical Property of 2-Methoxypyrimidine-5-carbaldehyde

Chemical Property:

• Boiling Point: 281.261 °C at 760 mmHg
• Flash Point: 123.902 °C C
• PSA: 52.08000
• Density: 1.238 g/cm³
• LogP: 0.29770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 138.042927438
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxypyrimidine-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC=C(C=N1)C=O

Technology Process of 2-Methoxypyrimidine-5-carbaldehyde

There total 6 articles about 2-Methoxypyrimidine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-iminiomethylvinamidinium trichloride + O-methylisourea hemisulfate (52328-05-9,24285-39-0) → 2-methoxy-pyrimidine-5-carbaldehyde (90905-32-1)

Guidance literature:

With potassium hydrogencarbonate; In Isopropyl acetate; water; at 20 ℃; for 40h;

DOI:10.1021/jo048082n

Reference yield: 80.0%

2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane bistetrafluoroborate + 2-methyl-isourea (2440-60-0) → 2-methoxy-pyrimidine-5-carbaldehyde (90905-32-1)

Guidance literature:

2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane bistetrafluoroborate; 2-methyl-isourea; With sodium ethanolate; In ethanol;

With hydrogenchloride; In tetrahydrofuran; ethanol; at 20 ℃;

Reference yield: 80.0%

2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate (2009-81-6) + O-methylisourea hemisulfate (29427-58-5,24285-39-0) → 2-methoxy-pyrimidine-5-carbaldehyde (90905-32-1)

Guidance literature:

With ethanol; sodium hydride; In ethanol; Heating;

upstream raw materials:

2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate

O-methylisourea hemisulfate

2-methyl-isourea

o-methylisourea hydrochloride

Downstream raw materials:

2-methoxy-5-vinylpyrimidine

2-benzyloxycarbonylamino-3-(2-methoxy-pyrimidin-5-yl)-acrylic acid methyl ester

5-((2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)-3-(2-methoxypyrimidin-5-yl)isoxazole

2-hydroxypyrimidine-5-carbaldehyde