Hydrazinecarbothioamide, N-phenyl-2-(2-thienylmethylene)-

Base Information

• Chemical Name: Hydrazinecarbothioamide, N-phenyl-2-(2-thienylmethylene)-
• CAS No.: 1435-01-4
• Molecular Formula: C12H11N3S2
• Molecular Weight: 261.371
• DSSTox Substance ID: DTXSID60359501
• Mol file: 1435-01-4.mol

Synonyms:1435-01-4;Hydrazinecarbothioamide, N-phenyl-2-(2-thienylmethylene)-;DTXSID60359501

Chemical Property of Hydrazinecarbothioamide, N-phenyl-2-(2-thienylmethylene)-

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 261.03943971
• Heavy Atom Count: 17
• Complexity: 275

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC(=S)NN=CC2=CC=CS2

Technology Process of Hydrazinecarbothioamide, N-phenyl-2-(2-thienylmethylene)-

There total 5 articles about Hydrazinecarbothioamide, N-phenyl-2-(2-thienylmethylene)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

thiophene-2-carbaldehyde (98-03-3) + 4-Phenyl-3-thiosemicarbazide (5351-69-9) → N-phenyl-2-(thiophen-2-ylmethylene)-hydrazinecarbothioamide (1435-01-4)

Guidance literature:

In methanol; Reflux;

DOI:10.1016/j.foodchem.2015.05.124

Reference yield: 80.0%

methyl 1-(thiophene-2-ylmethylene)-hydrazinecarbodithioate (26152-25-0) + aniline (62-53-3) → N-phenyl-2-(thiophen-2-ylmethylene)-hydrazinecarbothioamide (1435-01-4)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.bmcl.2008.09.097

Reference yield:

phenyl isothiocyanate (103-72-0) → N-phenyl-2-(thiophen-2-ylmethylene)-hydrazinecarbothioamide (1435-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / diethyl ether / 20 °C

2: methanol / 10.25 h / Reflux

With hydrazine hydrate; In methanol; diethyl ether;

DOI:10.1016/j.ejmech.2011.09.031

upstream raw materials:

thiophene-2-carbaldehyde

4-Phenyl-3-thiosemicarbazide

methyl 1-(thiophene-2-ylmethylene)-hydrazinecarbodithioate

aniline

Downstream raw materials:

N-phenyl-5-(thiophen-2-yl)-1,3,4-thiadiazole-2-amine

4-amino-2,7-dinitro-4'-phenylspiro(fluoren-9,3'-[1,2,4]triazolidine)-5'-thione-1-(thiophen-2-carbonyl)

4-amino-2,7-dinitro-9-fluorenone

[4-phenyl-1-(thiophen-2-carbonyl)-3-thioxo-1,2,4-triazaspiro[4.5]deca-6,9-dien-8-ylidene]malononitrile