5-(CHLOROMETHYL)-2-HYDROXYBENZALDEHYDE

Base Information

• Chemical Name: 5-(CHLOROMETHYL)-2-HYDROXYBENZALDEHYDE
• CAS No.: 23731-06-8
• Molecular Formula: C8H7ClO2
• Molecular Weight: 170.595
• Hs Code.: 2913000090
• Mol file: 23731-06-8.mol

Synonyms:5-(Chloromethyl)salicylaldehyde;

Chemical Property of 5-(CHLOROMETHYL)-2-HYDROXYBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0021mmHg at 25°C
• Melting Point: 84-85 °C(Solv: ligroine (8032-32-4))
• Refractive Index: 1.619
• Boiling Point: 281.4 °C at 760 mmHg
• PKA: 7.93±0.31(Predicted)
• Flash Point: 124 °C
• PSA: 37.30000
• Density: 1.34 g/cm³
• LogP: 1.94350
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99.9% ^*data from raw suppliers

5-(Chloromethyl)-2-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(Chloromethyl)-2-hydroxybenzaldehyde (cas# 23731-06-8) is a useful reagent for the synthesis of bis-heterocyclic derivatives and benzo-fused macrocycles containing oxazolone or imidazolone subunits.

Technology Process of 5-(CHLOROMETHYL)-2-HYDROXYBENZALDEHYDE

There total 13 articles about 5-(CHLOROMETHYL)-2-HYDROXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + salicylaldehyde (90-02-8) → 5-(chloromethyl)salicylaldehyde (23731-06-8)

Guidance literature:

With hydrogenchloride; at 20 ℃;

DOI:10.1016/j.tetlet.2013.12.080

Reference yield: 68.8%

1,3,5-Trioxan (110-88-3) + salicylaldehyde (90-02-8) → 5-(chloromethyl)salicylaldehyde (23731-06-8)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

Reference yield: 36.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + salicylaldehyde (90-02-8) → 5-(chloromethyl)salicylaldehyde (23731-06-8) + 3-(chloromethyl)-2-hydroxybenzaldehyde

Guidance literature:

With hydrogenchloride; In water; at 50 - 70 ℃; for 3h;

DOI:10.1016/j.bmc.2017.06.041

upstream raw materials:

formaldehyd

salicylaldehyde

chloromethanol

2-methyl-benzyl alcohol

Downstream raw materials:

5-(trimethylammoniomethyl)salicylaldehyde chloride

5-(azidomethyl)-2-hydroxybenzaldehyde

5-(3-acetyl-4-hydroxybenzyl)-2-hydroxybenzaldehyde

5-(3-formyl-4-hydroxybenzyl)-2-hydroxybenzoic acid

Refernces

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• 4、 ?ivkovi?-Radovanovi?, V.,Andjelkovi?, L.,Milenkovi?, M. R.. "Synthesis and Antimicrobial Activity of (3-Formyl-4-hydroxybenzyl)triphenylphosphonium Chloride Acylhydrazones". . p. 1716 - 1720. Retrieved 2020.
• 5、 Mohammadikish, Maryam,Ghanbari, Sara. "Preparation of monodispersed metal-based infinite coordination polymer nanostructures and their good capability for metal oxide preparation". . p. 86 - 90. Retrieved 2018.
• 6、 Li, Zhifang,Wu, Shujie,Ding, Hong,Lu, Haiming,Liu, Jiayin,Huo, Qisheng,Guan, Jingqi,Kan, Qiubin. "Oxovanadium(iv) and iron(iii) salen complexes immobilized on amino-functionalized graphene oxide for the aerobic epoxidation of styrene". . p. 4220 - 4229. Retrieved 2013.
• 7、 Mekky, Ahmed E. M.,Sanad, Sherif M. H.. "Microwave-Assisted Synthesis of Novel Bis(thiazoles) Incorporating Piperazine Moiety". . p. 1560 - 1566. Retrieved 2019.
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• 9、 Zammataro, Agatino,Gangemi, Chiara Maria Antonietta,Pappalardo, Andrea,Toscano, Rosa Maria,Puglisi, Roberta,Nicotra, Giuseppe,Fragalà, Maria Elena,Tuccitto, Nunzio,Sfrazzetto, Giuseppe Trusso. "Covalently functionalized carbon nanoparticles with a chiral Mn-Salen: A new nanocatalyst for enantioselective epoxidation of alkenes". . p. 5255 - 5258. Retrieved 2019.
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