4-HYDROXYISOPHTHALALDEHYDE

Base Information

• Chemical Name: 4-HYDROXYISOPHTHALALDEHYDE
• CAS No.: 3328-70-9
• Molecular Formula: C8H6O3
• Molecular Weight: 150.134
• Hs Code.: 2912499000
• Mol file: 3328-70-9.mol

Synonyms:Isophthalaldehyde,4-hydroxy- (7CI,8CI);2,4-Diformylphenol;3-Formyl-4-hydroxybenzaldehyde;4-Hydroxybenzene-1,3-dicarboxaldehyde;4-Hydroxyisophthalaldehyde;5-Formylsalicylaldehyde;

Chemical Property of 4-HYDROXYISOPHTHALALDEHYDE

Chemical Property:

• Vapor Pressure: 0.00538mmHg at 25°C
• Melting Point: 109 °C
• Refractive Index: 1.672
• Boiling Point: 266 °C at 760mmHg
• PKA: 5.98±0.18(Predicted)
• Flash Point: 128.9 °C
• PSA: 54.37000
• Density: 1.35 g/cm³
• LogP: 1.01720
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxyisophthalaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXYISOPHTHALALDEHYDE

There total 21 articles about 4-HYDROXYISOPHTHALALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 3-(3-formyl-4-hydroxyphenyl)prop-2-enoate (269060-13-1) → 5-formyl-2-hydroxybenzaldehyde (3328-70-9)

Guidance literature:

With ozone; In dichloromethane; at -78 ℃;

DOI:10.1080/00397910008087117

Reference yield: 80.0%

6-formyl-1',3',3'-trimethylspiro<2H-1-benzopyran-2,2'-<1H>-indole> (20200-69-5) → 5-formyl-2-hydroxybenzaldehyde (3328-70-9)

Guidance literature:

With ozone; In methanol; at -78 ℃; for 0.0833333h;

DOI:10.1016/S0040-4039(00)00516-5

Reference yield: 66.0%

hexamethylenetetramine (100-97-0) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-formyl-2-hydroxybenzaldehyde (3328-70-9)

Guidance literature:

With trifluoroacetic acid; at 90 ℃; for 24h;

upstream raw materials:

5-(chloromethyl)salicylaldehyde

2-hydroxy-5-formylbenzoic acid

5-hydroxymethylsalicylaldehyde

chloroform

Downstream raw materials:

5-chloromethyl-4-hydroxy-isophthalaldehyde

3,4-dihydroxybenzaldehyde

5-(3-formyl-4-hydroxyphenyl)-13,17-dibutyl-2,3,7,8,12,18-hexamethylporphine

2-(3-Fluoro-4-methoxy-benzoyl)-benzofuran-5-carbaldehyde