Ethanone, 1-(4-chlorophenyl)-2-[(4,5-dihydro-2-thiazolyl)thio]-

Base Information

• Chemical Name: Ethanone, 1-(4-chlorophenyl)-2-[(4,5-dihydro-2-thiazolyl)thio]-
• CAS No.: 143543-83-3
• Molecular Formula: C11H10ClNOS2
• Molecular Weight: 271.791
• DSSTox Substance ID: DTXSID00357763
• Wikidata: Q82137840
• ChEMBL ID: CHEMBL1407927
• Mol file: 143543-83-3.mol

Synonyms:143543-83-3;Ethanone, 1-(4-chlorophenyl)-2-[(4,5-dihydro-2-thiazolyl)thio]-;CBMicro_027068;Cambridge id 5658309;MLS001005087;CHEMBL1407927;SCHEMBL14408083;DTXSID00357763;HMS2714M05;AKOS000809365;SMR000377955;BIM-0027161.P001;AB00092109-01;Z56859241;1-(4-chlorophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylthio)ethanone

Chemical Property of Ethanone, 1-(4-chlorophenyl)-2-[(4,5-dihydro-2-thiazolyl)thio]-

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 270.9892340
• Heavy Atom Count: 16
• Complexity: 288

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CSC(=N1)SCC(=O)C2=CC=C(C=C2)Cl

Technology Process of Ethanone, 1-(4-chlorophenyl)-2-[(4,5-dihydro-2-thiazolyl)thio]-

There total 1 articles about Ethanone, 1-(4-chlorophenyl)-2-[(4,5-dihydro-2-thiazolyl)thio]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-mercaptothiazoline (96-53-7) + 4-chlorobenzoylmethyl bromide (536-38-9) → 1-(4-chlorophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-ethanone (143543-83-3)

Guidance literature:

2-mercaptothiazoline; With sodium carbonate; In ethanol; water; at 20 ℃;

4-chlorobenzoylmethyl bromide; In ethanol; water; at 20 ℃;

DOI:10.1016/j.jfluchem.2009.12.022

Reference yield: 68.0%

1-(4-chlorophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-ethanone (143543-83-3) → 2-(4,5-dihydrothiazol-2-ylsulfonyl)-1-(4-chlorophenyl)ethanone (1241899-65-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃;

DOI:10.1016/j.jfluchem.2009.12.022

Reference yield: 68.0%

semicarbazide hydrochloride (563-41-7) + 1-(4-chlorophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-ethanone (143543-83-3) → 2-[(Z)-2-[2-[(Z)-2-(aminocarbonyl)hydrazono]-2-(4-chlorophenyl)ethyl]disulfanyl-1-(4-chlorophenyl)ethylidene]-1-hydrazinecarboxamide (1277181-65-3)

Guidance literature:

With tetrabutylammomium bromide; sodium acetate; In 1,4-dioxane; water; at 20 ℃; for 72h;

DOI:10.1080/17415993.2010.533772

upstream raw materials:

2-mercaptothiazoline

4-chlorobenzoylmethyl bromide

Downstream raw materials:

2-(4,5-dihydrothiazol-2-ylsulfonyl)-1-(4-chlorophenyl)ethanone

2-[(Z)-2-[2-[(Z)-2-(aminocarbonyl)hydrazono]-2-(4-chlorophenyl)ethyl]disulfanyl-1-(4-chlorophenyl)ethylidene]-1-hydrazinecarboxamide

3,6-bis(4-chlorophenyl)-2,7-dihydro-1,4,5-thiadiazepine

C₁₁H₁₀ClNOS

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