Butanedioic acid, [tetrahydro-4-oxo-3,5-bis(phenylmethyl)-1,3,5-triazin-1(2H)-yl]-, 1-(1,1-dimethylethyl) ester, (S)-

Base Information

Chemical Name:Butanedioic acid, [tetrahydro-4-oxo-3,5-bis(phenylmethyl)-1,3,5-triazin-1(2H)-yl]-, 1-(1,1-dimethylethyl) ester, (S)-
CAS No.:143565-63-3
Molecular Formula:C25H31N3O5
Molecular Weight:453.538
Hs Code.:
Mol file:143565-63-3.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Butanedioic acid, [tetrahydro-4-oxo-3,5-bis(phenylmethyl)-1,3,5-triazin-1(2H)-yl]-, 1-(1,1-dimethylethyl) ester, (S)-

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Technology Process of Butanedioic acid, [tetrahydro-4-oxo-3,5-bis(phenylmethyl)-1,3,5-triazin-1(2H)-yl]-, 1-(1,1-dimethylethyl) ester, (S)-

There total 1 articles about Butanedioic acid, [tetrahydro-4-oxo-3,5-bis(phenylmethyl)-1,3,5-triazin-1(2H)-yl]-, 1-(1,1-dimethylethyl) ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 143565-41-7
1-O-tert-butyl 4-O-benzyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)succinate

: 143565-63-3
(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-succinic acid 1-tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 0.333333h; under 760 Torr;
DOI:10.1021/jo00049a036

Reference yield:

: 143565-63-3
(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-succinic acid 1-tert-butyl ester

: 143565-78-0
tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1) iPrOCOCl, N-methylmorpholine, 2) NaBH₄ / 1) DME, -20 deg c, 5 min, 2) H₂O, 0 to 23 deg C

2: 1) (COCl)2, DMSO, 2) i-Pr₂NEt / 1) CH₂Cl₂, T < -50 deg C, 20 min, 2) -50 to 0 deg -C

3: 61 percent / toluene / 1 h / Heating

4: 79 percent / H₂ / 10percent Pd-C / ethyl acetate / 0.33 h / 760 Torr

With 4-methyl-morpholine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; dimethyl sulfoxide; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethyl acetate; toluene;
DOI:10.1021/jo00049a036

Reference yield:

: 143565-63-3
(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-succinic acid 1-tert-butyl ester

: 143565-82-6
tert-butyl 7-aza-2(S)-<(tert-butoxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-9(R)-hydroxyundecanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1) iPrOCOCl, N-methylmorpholine, 2) NaBH₄ / 1) DME, -20 deg c, 5 min, 2) H₂O, 0 to 23 deg C

2: 1) (COCl)2, DMSO, 2) i-Pr₂NEt / 1) CH₂Cl₂, T < -50 deg C, 20 min, 2) -50 to 0 deg -C

3: 61 percent / toluene / 1 h / Heating

4: 79 percent / H₂ / 10percent Pd-C / ethyl acetate / 0.33 h / 760 Torr

5: 1) molecular sieves 4 Angstroem, 2) H₂ / 2) PtO₂ / 1) benzene, RT, 3 h, 2) THF, 23 deg C, 760 torr, 6 h

With 4-methyl-morpholine; sodium tetrahydroborate; oxalyl dichloride; 4 A molecular sieve; hydrogen; dimethyl sulfoxide; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; palladium on activated charcoal; In ethyl acetate; toluene;
DOI:10.1021/jo00049a036