tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate

Base Information

Chemical Name:tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate
CAS No.:143565-78-0
Molecular Formula:C₂₇H₃₅N₃O₄
Molecular Weight:465.593
Hs Code.:

Synonyms:tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate

Suppliers and Price of tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate

There total 5 articles about tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 143565-66-6
(E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester

: 143565-78-0
tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 0.333333h; under 760 Torr;
DOI:10.1021/jo00049a036

Reference yield:

: 143565-77-9
tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-4-oxobutyrate

: 143565-78-0
tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / toluene / 1 h / Heating

2: 79 percent / H₂ / 10percent Pd-C / ethyl acetate / 0.33 h / 760 Torr

With hydrogen; palladium on activated charcoal; In ethyl acetate; toluene;
DOI:10.1021/jo00049a036

Reference yield:

: 143565-41-7
1-O-tert-butyl 4-O-benzyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)succinate

: 143565-78-0
tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-6-oxohexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂ / 10percent Pd-C / methanol / 0.33 h / 760 Torr

2: 1) iPrOCOCl, N-methylmorpholine, 2) NaBH₄ / 1) DME, -20 deg c, 5 min, 2) H₂O, 0 to 23 deg C

3: 1) (COCl)2, DMSO, 2) i-Pr₂NEt / 1) CH₂Cl₂, T < -50 deg C, 20 min, 2) -50 to 0 deg -C

4: 61 percent / toluene / 1 h / Heating

5: 79 percent / H₂ / 10percent Pd-C / ethyl acetate / 0.33 h / 760 Torr

With 4-methyl-morpholine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; dimethyl sulfoxide; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethyl acetate; toluene;
DOI:10.1021/jo00049a036