(E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester

Base Information

Chemical Name:(E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester
CAS No.:143565-66-6
Molecular Formula:C₂₇H₃₃N₃O₄
Molecular Weight:463.577
Hs Code.:

Synonyms:(E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester

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Chemical Property of (E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester

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Technology Process of (E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester

There total 4 articles about (E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 2136-75-6
(triphenylphosphoranylidene)acetaldehyde

: 143565-77-9
tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-4-oxobutyrate

: 143565-66-6
(E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester

Guidance literature:: In toluene; for 1h; Heating;
DOI:10.1021/jo00049a036

Reference yield:

: 143565-41-7
1-O-tert-butyl 4-O-benzyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)succinate

: 143565-66-6
(E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂ / 10percent Pd-C / methanol / 0.33 h / 760 Torr

2: 1) iPrOCOCl, N-methylmorpholine, 2) NaBH₄ / 1) DME, -20 deg c, 5 min, 2) H₂O, 0 to 23 deg C

3: 1) (COCl)2, DMSO, 2) i-Pr₂NEt / 1) CH₂Cl₂, T < -50 deg C, 20 min, 2) -50 to 0 deg -C

4: 61 percent / toluene / 1 h / Heating

With 4-methyl-morpholine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; dimethyl sulfoxide; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; toluene;
DOI:10.1021/jo00049a036

Reference yield:

: 143565-76-8
tert-butyl 2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-4-hydroxybutyrate

: 143565-66-6
(E)-(S)-2-(3,5-Dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-6-oxo-hex-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) (COCl)2, DMSO, 2) i-Pr₂NEt / 1) CH₂Cl₂, T < -50 deg C, 20 min, 2) -50 to 0 deg -C

2: 61 percent / toluene / 1 h / Heating

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In toluene;
DOI:10.1021/jo00049a036