Propanedioic acid, [6-(phenylmethoxy)-2-(2-propenyl)hexyl]-, diethyl ester, (R)-

Base Information

Chemical Name:Propanedioic acid, [6-(phenylmethoxy)-2-(2-propenyl)hexyl]-, diethyl ester, (R)-
CAS No.:143761-27-7
Molecular Formula:C₂₃H₃₄O₅
Molecular Weight:390.52
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanedioic acid, [6-(phenylmethoxy)-2-(2-propenyl)hexyl]-, diethyl ester, (R)-

Chemical Property:

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Technology Process of Propanedioic acid, [6-(phenylmethoxy)-2-(2-propenyl)hexyl]-, diethyl ester, (R)-

There total 6 articles about Propanedioic acid, [6-(phenylmethoxy)-2-(2-propenyl)hexyl]-, diethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130892-97-6
6-benzyloxyhexanoic acid

: 143761-27-7
(4S)-ethyl-4-allyl-8-(benzyloxy)-2-carbethoxyoctanoate

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / diethyl ether / 2 h / 0 °C

2: 1.) n-BuLi / 1.) THF, hexane, 2.) THF, from -78 deg to RT, 1 h

3: 1.) LDA / 1) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -10 deg C, 2 h

4: 83 percent / LiBH₄, H₂O / diethyl ether; tetrahydrofuran / 0.5 h / 0 - 20 °C

5: 100 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

6: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, reflux, 18 h

With lithium borohydride; n-butyllithium; water; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm00054a003

Reference yield:

: C₁₈H₂₆O₄

: 143761-27-7
(4S)-ethyl-4-allyl-8-(benzyloxy)-2-carbethoxyoctanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, hexane, 2.) THF, from -78 deg to RT, 1 h

2: 1.) LDA / 1) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -10 deg C, 2 h

3: 83 percent / LiBH₄, H₂O / diethyl ether; tetrahydrofuran / 0.5 h / 0 - 20 °C

4: 100 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

5: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, reflux, 18 h

With lithium borohydride; n-butyllithium; water; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm00054a003

Reference yield:

: 143761-25-5
2(R)-allyl-6-(benzyloxy)hexan-1-ol

: 143761-27-7
(4S)-ethyl-4-allyl-8-(benzyloxy)-2-carbethoxyoctanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, reflux, 18 h

With sodium hydride; triethylamine; In dichloromethane;
DOI:10.1021/jm00054a003