Benzeneethanesulfonamide, N-(phenylmethyl)-

Base Information

• Chemical Name: Benzeneethanesulfonamide, N-(phenylmethyl)-
• CAS No.: 143769-63-5
• Molecular Formula: C15H17NO2S
• Molecular Weight: 275.371
• Mol file: 143769-63-5.mol

Synonyms:

Chemical Property of Benzeneethanesulfonamide, N-(phenylmethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneethanesulfonamide, N-(phenylmethyl)-

There total 3 articles about Benzeneethanesulfonamide, N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-phenylethylsulfonyl chloride (4025-71-2) + benzylamine (100-46-9) → N-benzyl 2-phenylethanesulfonamide (143769-63-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 12h;

DOI:10.1002/chem.201602138

Reference yield:

S-2-phenylethyl thioacetate (35065-97-5) → N-benzyl 2-phenylethanesulfonamide (143769-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide; hydrogenchloride / acetonitrile / 0 °C

2: triethylamine / dichloromethane / 12 h / 0 - 25 °C

With hydrogenchloride; N-chloro-succinimide; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1002/chem.201602138

Reference yield:

1-phenyl-2-bromoethane (103-63-9) → N-benzyl 2-phenylethanesulfonamide (143769-63-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 2 h / 0 - 25 °C

2: N-chloro-succinimide; hydrogenchloride / acetonitrile / 0 °C

3: triethylamine / dichloromethane / 12 h / 0 - 25 °C

With hydrogenchloride; N-chloro-succinimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/chem.201602138

upstream raw materials:

2-phenylethylsulfonyl chloride

benzylamine

S-2-phenylethyl thioacetate

1-phenyl-2-bromoethane

Downstream raw materials:

3,4-dihydro-1H-benzo[c][1,2]thiazine 2,2-dioxide

N-benzyl-1,2,4,5-tetrahydro-3,2-benzothiazepine 3,3-dioxide

1,2,4,5-tetrahydrobenzo[d][1,2]thiazepine-3,3-dioxide

N-4-methylphenylsulfonyl-1,2,4,5-tetrahydro-3,2-benzothiazepine 3,3-dioxide

Refernces

• 1、 Zinczuk, Juan,Sorokin, Isidoro H.,Orazi, Orfeo O.,Corral, Renee A.. "Intramolecular Sulphonamidomethylation. Part II. Fused Heterocycles from 2-Phenylethanesulphonamides". . p. 859 - 866. Retrieved 2007/10/02.