4-(4-Benzoylphenyl)-1-phenylbutan-1-one

Base Information

• Chemical Name: 4-(4-Benzoylphenyl)-1-phenylbutan-1-one
• CAS No.: 143859-51-2
• Molecular Formula: C23H20O2
• Molecular Weight: 328.411
• DSSTox Substance ID: DTXSID20577704
• Wikidata: Q82467782
• Mol file: 143859-51-2.mol

Synonyms:4-(4-Benzoylphenyl)-1-phenylbutan-1-one;143859-51-2;DTXSID20577704

Chemical Property of 4-(4-Benzoylphenyl)-1-phenylbutan-1-one

Chemical Property:

• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 328.146329876
• Heavy Atom Count: 25
• Complexity: 421

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)CCCC2=CC=C(C=C2)C(=O)C3=CC=CC=C3

Technology Process of 4-(4-Benzoylphenyl)-1-phenylbutan-1-one

There total 6 articles about 4-(4-Benzoylphenyl)-1-phenylbutan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-phenyl-1-cyclobutanol (935-64-8) + 4-phenylcabonylphenyl pivalate (112004-82-7) → 4-(4-benzoylphenyl)-1-phenylbutan-1-one (143859-51-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; lithium tert-butoxide; tricyclohexylphosphine; In toluene; at 80 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1002/cjoc.202000319

Reference yield:

4-Hydroxybenzophenone (1137-42-4) → 4-(4-benzoylphenyl)-1-phenylbutan-1-one (143859-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; lithium tert-butoxide; tricyclohexylphosphine / toluene / 12 h / 80 °C / Sealed tube; Inert atmosphere

With dmap; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; triethylamine; lithium tert-butoxide; tricyclohexylphosphine; In dichloromethane; toluene;

DOI:10.1002/cjoc.202000319

Reference yield:

phenylmagnesium bromide (100-58-3) → 4-(4-benzoylphenyl)-1-phenylbutan-1-one (143859-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; lithium tert-butoxide; tricyclohexylphosphine / toluene / 12 h / 80 °C / Sealed tube; Inert atmosphere

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; lithium tert-butoxide; tricyclohexylphosphine; In tetrahydrofuran; diethyl ether; toluene;

DOI:10.1002/cjoc.202000319

upstream raw materials:

carbon disulfide

aluminium trichloride

1,4-diphenylbutan-1-one

benzoyl chloride