Acetamide, N-(2-ethenylphenyl)-2,2,2-trifluoro-

Base Information

Chemical Name:Acetamide, N-(2-ethenylphenyl)-2,2,2-trifluoro-
CAS No.:143879-49-6
Molecular Formula:C10H8F3NO
Molecular Weight:215.175
Hs Code.:
DSSTox Substance ID:DTXSID60456206
Wikidata:Q82278458
Mol file:143879-49-6.mol

Synonyms:Acetamide, N-(2-ethenylphenyl)-2,2,2-trifluoro-;143879-49-6;N-(2-ETHENYLPHENYL)-2,2,2-TRIFLUOROACETAMIDE;N-trifluoroacetyl-2-vinylaniline;DTXSID60456206

Suppliers and Price of Acetamide, N-(2-ethenylphenyl)-2,2,2-trifluoro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Acetamide, N-(2-ethenylphenyl)-2,2,2-trifluoro-

Chemical Property:

PSA：32.59000
LogP:3.47990
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:215.05579836
Heavy Atom Count:15
Complexity:250

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=CC1=CC=CC=C1NC(=O)C(F)(F)F

Technology Process of Acetamide, N-(2-ethenylphenyl)-2,2,2-trifluoro-

There total 3 articles about Acetamide, N-(2-ethenylphenyl)-2,2,2-trifluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3867-18-3
2-vinylaniline

: 407-25-0
trifluoroacetic anhydride

: 143879-49-6
2,2,2-trifluoro-N-(2-vinylphenyl)acetamide

Guidance literature:

Reference yield:

: 615-36-1
2-bromoaniline

: 143879-49-6
2,2,2-trifluoro-N-(2-vinylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 °C / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.5 h / Reflux; Inert atmosphere; Schlenk technique

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In dichloromethane; toluene;
DOI:10.1002/ejic.201800251

Reference yield:

: 2727-71-1
N-(2-bromophenyl)-2,2,2-trifluoroacetamide

: potassium vinyltrifluoroborate

: 143879-49-6
2,2,2-trifluoro-N-(2-vinylphenyl)acetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triphenylphosphine; In tetrahydrofuran; water; for 22h; Inert atmosphere; Reflux;
DOI:10.1002/chem.201103973