3-(2-Hydroxyphenyl)isoquinolin-1(2H)-one

Base Information

Chemical Name:3-(2-Hydroxyphenyl)isoquinolin-1(2H)-one
CAS No.:143882-36-4
Molecular Formula:C15H11NO2
Molecular Weight:237.258
Hs Code.:
DSSTox Substance ID:DTXSID10579752
Wikidata:Q82470365
Mol file:143882-36-4.mol

Synonyms:3-(2-Hydroxyphenyl)isoquinolin-1(2H)-one;143882-36-4;DTXSID10579752

Suppliers and Price of 3-(2-Hydroxyphenyl)isoquinolin-1(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 3-(2-Hydroxyphenyl)isoquinolin-1(2H)-one

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:237.078978594
Heavy Atom Count:18
Complexity:364

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=C(NC2=O)C3=CC=CC=C3O

Technology Process of 3-(2-Hydroxyphenyl)isoquinolin-1(2H)-one

There total 7 articles about 3-(2-Hydroxyphenyl)isoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 81450-25-1
2-hydroxy-2'-carboxydeoxybenzoin

: 143882-36-4
3-(2-hydroxy-phenyl)-2H-isoquinolin-1-one

Guidance literature:: With ammonium acetate; at 100 ℃; for 3h;
DOI:10.1039/P19920001769

Reference yield: 81.0%

: 1160642-77-2
3-(2-methoxymethoxy-phenyl)-2H-isoquinolin-1-one

: 143882-36-4
3-(2-hydroxy-phenyl)-2H-isoquinolin-1-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;
DOI:10.1016/j.tetlet.2014.01.020

Reference yield:

: 56290-53-0
1-(2-methoxyphenyl)butane-1,3-dione

: 143882-36-4
3-(2-hydroxy-phenyl)-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / NaOEt, Cu powder / ethanol / 12 h / Heating

2: 45 percent / NaCN / dimethylsulfoxide / 48 h / 160 °C

3: 94 percent / NH₄OAc / 3 h / 100 °C

With sodium cyanide; ammonium acetate; sodium ethanolate; copper; In ethanol; dimethyl sulfoxide;
DOI:10.1039/P19920001769