56290-53-0

Usage

Uses

Used in Cosmetic Industry:
1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE is used as a UV filter for its ability to absorb and filter UV radiation, providing sun protection in sunscreen and other personal care products.
Used in Pharmaceutical Industry:
1-(2-METHOXY-PHENYL)-BUTANE-1,3-DIONE is used as an ingredient in pharmaceutical products due to its potential antioxidant and anti-inflammatory properties, which are currently being studied for their health effects and efficacy.

InChI:InChI=1/C11H12O3/c1-8(12)7-10(13)9-5-3-4-6-11(9)14-2/h3-6H,7H2,1-2H3

Upstream product

• 578-57-4 2-bromoanisole 
• 529-28-2 4-iodoanisol 
• 201230-82-2 carbon monoxide 
• 67-64-1 acetone 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 579-74-8 2-Methoxyacetophenone 
• 141-78-6 ethyl acetate 
• 606-45-1 2-methoxybenzoic acid methyl ester 

Downstream Products

• 117184-80-2 1-(2-Methoxy-phenyl)-2-(2-methyl-[1,3]dithiolan-2-yl)-ethanone 
• 1733-52-4 1-(diphenylphosphinoyl)propan-2-one 
• 56945-03-0 2-(1,3-dithiolan-2-ylidene)-1-(2-methoxyphenyl)ethanone 
• 5751-48-4 2-methylchromone 
• 1210068-78-2 C₂₃H₂₂O₁₀ 
• 1210068-92-0 C₂₃H₂₂O₁₀ 
• 1135793-47-3 3-[(2,2-dimethoxyethyl)amino]-1-(2-methoxyphenyl)but-2-en-1-one 
• 143882-38-6 3-(2-Hydroxyphenyl)-2-phenylisoquinolin-1(2H)-one 
• 143882-37-5 2-Ethyl-3-(2-hydroxyphenyl)isoquinolin-1(2H)-one 
• 143882-36-4 3-(2-hydroxy-phenyl)-2H-isoquinolin-1-one 
• 81450-25-1 2-hydroxy-2'-carboxydeoxybenzoin 

Relevant academic research and scientific papers

I2-Promoted [3+2] Cyclization of 1,3-Diketones with Potassium Thiocyanate: a Route to Thiazol-2(3H)-One Derivatives

An I2-promoted strategy has been developed for the synthesis of thiazol-2(3H)-one derivatives from 1,3-diketones with potassium thiocyanate. This [3+2] cyclization reaction involves C?S and C?N bond formation and exhibits good functional group tolerance. A series of thiazol-2(3H)-one derivatives are obtained in moderate to good yields. (Figure presented.).

Rhodium(ii)-catalysed generation of cycloprop-1-en-1-yl ketones and their rearrangement to 5-aryl-2-siloxyfurans

Donor-acceptor cyclopropenes formed from enoldiazoketones undergo catalytic rearrangement to 5-aryl-2-siloxyfurans via a novel mechanism that involves a nucleophilic addition of the carbonyl oxygen to the rhodium-activated cyclopropene.

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.

Direct route to 1,3-diketones by palladium-catalyzed carbonylative coupling of aryl halides with acetylacetone

Man up your magnesium! By employing a MgCl2/Et3N system, aryl diketones can be generated from the Pd-catalyzed carbonylative α-arylation of acetylacetone with aryl bromides (see scheme). The method is ideal for the introduction of carbon isotopes into more complex structures, since only stoichiometric amounts of carbon monoxide are employed. Copyright

Palladium-catalysed carbonylative α-arylation of acetone and acetophenones to 1,3-diketones

Three COmponent α-arylation: A carbonylative ketone α-arylation process employing acetone for the first time, as well as acetophenones, is described (see scheme). The reaction tolerates a range of (hetero)aryl iodides and several functionalised aryl ketone coupling partners. Only low pressures of molecular CO are applied and no additional solvent is necessary. Copyright

Regioselective synthesis of 4-chlorophenols, 10-chloro-7-hydroxy-6H-benzo[c]chromen-6-ones, and 4-chloro-1-hydroxy-9H-fluoren-9-ones based on [3+3] cyclizations of 1,3-bis(silyloxy)-1,3-dienes with 2-chloro-3-silyloxy-2-en-1-ones

A variety of 4-chlorophenols, 10-chloro-7-hydroxy-6H-benzo[c]chromen-6-ones, and 4-chloro-1-hydroxy-9H-fluoren-9-ones were prepared by formal [3+3] cyclizations of 1,3-bis(silyloxy)-1,3-dienes with 2-chloro-3-(silyloxy)alk-2-en-1-ones.

Triketoacid inhibitors of HIV-integrase: A new chemotype useful for probing the integrase pharmacophore

Integrase is one of three enzymes expressed by HIV and represents a validated target for therapy. This study reports on the discovery of a new triketoacid-based chemotype that selectively inhibits the strand transfer reaction of HIV-integrase. SAR studies showed that the template binds to integrase in a manner similar to the diketoacid-based inhibitors. Moreover, comparison of the new chemotype to two different diketoacid templates led us to propose two aryl-binding domains in the inhibitor binding site. This information was used to design a new diketoacid template with improved activity against the enzyme.