1160642-77-2

Upstream product

• 2728-04-3 N,N-diethyl-ortho-toluamide 
• 118-90-1 ortho-methylbenzoic acid 
• 611-20-1 salicylonitrile 
• 933-88-0 ortho-toluoyl chloride 

Downstream Products

• 1272658-52-2 C₂₅H₂₃NO₄ 
• 1160642-79-4 3-(2-methoxymethoxy-phenyl)-2-methyl-2H-isoquinolin-1-one 
• 1352286-97-5 3-(2-hydroxy-phenyl)-2-methyl-2H-isoquinolin-1-one 
• 1352286-99-7 3-(2-hydroxy-phenyl)-2-methyl-1-oxo-1,2-dihydro-isoquinoline-4-carbaldehyde 
• 143882-36-4 3-(2-hydroxy-phenyl)-2H-isoquinolin-1-one 

Relevant academic research and scientific papers

Synthesis of novel 5-oxaprotoberberines as bioisosteres of protoberberines

5-Oxaprotoberberinones and 5-oxaprotoberberinium were synthesized as bioisosteres of protoberberines. 5-Oxaprotoberberinones were prepared by linking phenol with the isoquinolone ring of 3-phenolisoquinolones by methyleneoxy bridge, while the quaternary 5-oxaprotoberberinium salt was synthesized by reduction and oxidation of the lactam moiety of 5-oxaprotoberberinone.

Synthesis of 12-oxobenzo[c]phenanthridinones and 4-substituted 3-arylisoquinolones via Vilsmeier-Haack reaction

Vilsmeier-Haack reaction on 3-arylisoquinolones resulted in versatile 4-formylated 3-arylisoquinolones that were further derivatized into 12-oxobenzo[c]phenanthridinones, 4-alkoxymethyl-3-arylisoquinolones, 3-aryl-4-phenoxymethylisoquinolones, 4-aminometh

Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors

Benz[b]oxepines 4a-g and 12-oxobenzo[c]phenanthridines 5a-d were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular radical cyclization reaction. Radical cyclization of O-vinyl compounds preferentially led to th