L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucyl-D-2-piperidinecarbonyl- L-2-piperidinecarbonyl-D-phenylalanyl-, phenylmethyl ester

Base Information

Chemical Name:L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucyl-D-2-piperidinecarbonyl- L-2-piperidinecarbonyl-D-phenylalanyl-, phenylmethyl ester
CAS No.:144073-31-4
Molecular Formula:C54H63N5O8
Molecular Weight:910.123
Hs Code.:
Mol file:144073-31-4.mol

L-Proline,
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucyl-D-2-piperidinecarbonyl-
L-2-piperidinecarbonyl-D-phenylalanyl-, phenylmethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucyl-D-2-piperidinecarbonyl- L-2-piperidinecarbonyl-D-phenylalanyl-, phenylmethyl ester

Chemical Property:

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Technology Process of L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucyl-D-2-piperidinecarbonyl- L-2-piperidinecarbonyl-D-phenylalanyl-, phenylmethyl ester

There total 7 articles about L-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isoleucyl-D-2-piperidinecarbonyl- L-2-piperidinecarbonyl-D-phenylalanyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1026676-51-6
D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

: 103321-51-3
((1S,2S)-1-Chlorocarbonyl-2-methyl-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

: 144073-31-4
Fmoc-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Guidance literature:: With silver cyanide; In toluene; at 80 - 85 ℃; for 0.5h;
DOI:10.1021/jm00099a019

Reference yield:

: 1027545-12-5
L-Pip-D-Phe-L-Pro-OCH₂Ph

: 144073-31-4
Fmoc-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / N,N-diisopropylethylamine (DIEA) / CH₂Cl₂ / 2 h / pH 8

2: diethylamine / acetonitrile / Ambient temperature

3: 78 percent / AgCN / toluene / 0.5 h / 80 - 85 °C

With silver cyanide; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm00099a019

Reference yield:

: 96935-61-4
H-D-Phe-L-Pro-OCH₂Ph hydrochloride

: 144073-31-4
Fmoc-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / N,N-diisopropylethylamine (DIEA) / CH₂Cl₂ / 2 h / pH 8

2: diethylamine / acetonitrile / Ambient temperature

3: 89 percent / N,N-diisopropylethylamine (DIEA) / CH₂Cl₂ / 2 h / pH 8

4: diethylamine / acetonitrile / Ambient temperature

5: 78 percent / AgCN / toluene / 0.5 h / 80 - 85 °C

With silver cyanide; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm00099a019