2-Propenoic acid, 2-cyano-3-[(1-cyano-2-ethoxy-2-oxoethyl)thio]-3-(phenylamino)-, ethyl ester

Base Information

• Chemical Name: 2-Propenoic acid, 2-cyano-3-[(1-cyano-2-ethoxy-2-oxoethyl)thio]-3-(phenylamino)-, ethyl ester
• CAS No.: 144558-54-3
• Molecular Formula: C₁₇H₁₇N₃O₄S
• Molecular Weight: 359.406
• Mol file: 144558-54-3.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 2-cyano-3-[(1-cyano-2-ethoxy-2-oxoethyl)thio]-3-(phenylamino)-, ethyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 2-cyano-3-[(1-cyano-2-ethoxy-2-oxoethyl)thio]-3-(phenylamino)-, ethyl ester

There total 1 articles about 2-Propenoic acid, 2-cyano-3-[(1-cyano-2-ethoxy-2-oxoethyl)thio]-3-(phenylamino)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl bromocyanoacetate (1187-46-8) + phenyl isothiocyanate (103-72-0) + ethyl 2-cyanoacetate (105-56-6) → (E)-2-Cyano-3-(cyano-ethoxycarbonyl-methylsulfanyl)-3-phenylamino-acrylic acid ethyl ester (144558-54-3)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1.) DMF, RT, 24 h, 2.) DMF, RT, 24 h;

DOI:10.1135/cccc19921747

Reference yield: 71.0%

(E)-2-Cyano-3-(cyano-ethoxycarbonyl-methylsulfanyl)-3-phenylamino-acrylic acid ethyl ester (144558-54-3) → 4-amino-2-anilino-5-cyano-thiophene-3-carboxylic acid ethyl ester (59615-87-1)

Guidance literature:

With sodium hydroxide; In ethanol; for 6h; Heating;

DOI:10.1135/cccc19921747

Reference yield:

(E)-2-Cyano-3-(cyano-ethoxycarbonyl-methylsulfanyl)-3-phenylamino-acrylic acid ethyl ester (144558-54-3) → 3-amino-2-cyano-5-phenylamino-4-phenylcarbamoylthiophene (144558-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / NaOH / ethanol / 6 h / Heating

2: 72 percent / 2 h / 160 °C

With sodium hydroxide; In ethanol;

DOI:10.1135/cccc19921747

upstream raw materials:

ethyl bromocyanoacetate

phenyl isothiocyanate

ethyl 2-cyanoacetate

Downstream raw materials:

4-amino-2-anilino-5-cyano-thiophene-3-carboxylic acid ethyl ester

3-amino-2-cyano-5-phenylamino-4-phenylcarbamoylthiophene

4-cyano-2-methyl-7-oxo-1-phenyl-6-phenylaminothieno<3,4-d>pyrimidine

Refernces